San Francisco 49ers predictions

Upcoming odds, recent results, and verified handicappers who have performed best on games involving San Francisco 49ers.

Odds & predictions

Upcoming matchups

Sept 20, 2026Sunday @ 4:25PM ET

Miami DolphinsSpread +13 (-108)Moneyline +625

VS

San Francisco 49ersSpread -13 (-108)Moneyline -950

Over/Under45.5 (-110)View predictions

Sept 27, 2026Sunday @ 4:05PM ET

Arizona CardinalsSpread +11.5 (-110)Moneyline +470

VS

San Francisco 49ersSpread -11.5 (-110)Moneyline -650

Over/Under46.5 (-110)View predictions

Head-to-head history

Past games

164 final results in SportsJaw history

Sep 10, 2026

San Francisco 49ers27Los Angeles Rams7Final

Jan 17, 2026

San Francisco 49ers6Seattle Seahawks41Final

Jan 11, 2026

San Francisco 49ers23Philadelphia Eagles19Final

Jan 3, 2026

Seattle Seahawks13San Francisco 49ers3Final

Dec 28, 2025

Expert grades use verified net profit on settled picks involving San Francisco 49ers, with a confidence adjustment until ten qualifying picks are recorded.