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Scores & odds

NFL Picks Today (9/27/2026)

Get today's NFL picks, expert predictions, odds and scores for September 27, 2026. Open any matchup for current lines, consensus picks and SportsJaw game analysis.

NFL picks and predictions

Date & timeMatchupSpreadMoneylineTotalPredictions
Sun, Sep 271:00 PM ET
New York JetsDetroit Lions
+6.5 (-105)-6.5 (-115)
+250-300
O 48.5 (-110)U 48.5 (-110)
View picks: New York Jets vs Detroit Lions prediction
View picks
Sun, Sep 271:00 PM ET
Houston TexansIndianapolis Colts
-1.5 (-110)+1.5 (-110)
-125+105
O 42.5 (-110)U 42.5 (-110)
View picks: Houston Texans vs Indianapolis Colts prediction
View picks
Sun, Sep 271:00 PM ET
New England PatriotsJacksonville Jaguars
+3 (-115)-3 (-105)
+130-150
O 46 (-110)U 46 (-110)
View picks: New England Patriots vs Jacksonville Jaguars prediction
View picks
Sun, Sep 271:00 PM ET
Carolina PanthersCleveland Browns
-2 (-110)+2 (-110)
-130+110
O 42 (-110)U 42 (-110)
View picks: Carolina Panthers vs Cleveland Browns prediction
View picks
Sun, Sep 271:00 PM ET
Los Angeles ChargersBuffalo Bills
+7 (-105)-7 (-115)
+274-340
O 50 (-112)U 50 (-108)
View picks: Los Angeles Chargers vs Buffalo Bills prediction
View picks
Sun, Sep 271:00 PM ET
Kansas City ChiefsMiami Dolphins
-9.5 (-110)+9.5 (-110)
-600+450
O 45 (-110)U 45 (-110)
View picks: Kansas City Chiefs vs Miami Dolphins prediction
View picks
Sun, Sep 271:00 PM ET
Cincinnati BengalsPittsburgh Steelers
-3 (-115)+3 (-105)
-170+150
O 42.5 (-110)U 42.5 (-110)
View picks: Cincinnati Bengals vs Pittsburgh Steelers prediction
View picks
Sun, Sep 271:00 PM ET
Tennessee TitansNew York Giants
+2.5 (-110)-2.5 (-110)
+115-135
O 37.5 (-110)U 37.5 (-110)
View picks: Tennessee Titans vs New York Giants prediction
View picks
Sun, Sep 271:00 PM ET
Seattle SeahawksWashington Commanders
-8.5 (-110)+8.5 (-110)
-410+320
O 40 (-114)U 40 (-107)
View picks: Seattle Seahawks vs Washington Commanders prediction
View picks
Sun, Sep 274:05 PM ET
Arizona CardinalsSan Francisco 49ers
+7.5 (-113)-7.5 (-107)
+296-370
O 48 (-113)U 48 (-107)
View picks: Arizona Cardinals vs San Francisco 49ers prediction
View picks
Sun, Sep 274:05 PM ET
Minnesota VikingsTampa Bay Buccaneers
-1 (-105)+1 (-112)
-115-105
O 42.5 (-108)U 42.5 (-110)
View picks: Minnesota Vikings vs Tampa Bay Buccaneers prediction
View picks
Sun, Sep 274:25 PM ET
Las Vegas RaidersNew Orleans Saints
+3.5 (-115)-3.5 (-105)
+155-180
O 43.5 (-110)U 43.5 (-108)
View picks: Las Vegas Raiders vs New Orleans Saints prediction
View picks
Sun, Sep 274:25 PM ET
Baltimore RavensDallas Cowboys
-3 (-120)+3 (+100)
-175+153
O 53.5 (-108)U 53.5 (-112)
View picks: Baltimore Ravens vs Dallas Cowboys prediction
View picks
Sun, Sep 278:20 PM ET
Los Angeles RamsDenver Broncos
-1.5 (-110)+1.5 (-108)
-130+110
O 44 (-110)U 44 (-110)
View picks: Los Angeles Rams vs Denver Broncos prediction
View picks

How to use today's NFL picks

SportsJaw's NFL picks today page brings the complete 9/27/2026 schedule, current odds, scores and published game predictions into one place. Open any matchup to compare market lines, community consensus, expert picks and SportsJaw's game analysis before making your selection.

Current sports predictionsNFL team predictionsNFL matchup history

NFL Team Predictions

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  • Kansas City Chiefs
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  • Los Angeles Chargers
  • Los Angeles Rams
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  • New Orleans Saints
  • New York Giants
  • New York Jets
  • NFC All-Stars
  • Philadelphia Eagles
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  • San Francisco 49ers
  • Seattle Seahawks
  • Tampa Bay Buccaneers
  • Tennessee Titans
  • Washington Commanders
Fresh analysis

Latest NFL predictions

Newly published game analysis, projected outcomes and betting leans from the SportsJaw Editorial Team.

View all predictions
NFL PicksSep 27, 2026, 9:15 AM EDT

Los Angeles Rams vs Denver Broncos prediction, odds and best bet for September 27

Our Rams vs Broncos forecast is Los Angeles 24, Denver 20. The rushing matchup favors the Rams, but the spread and 44-point total are passes.

Read prediction
NFL PicksSep 27, 2026, 9:06 AM EDT

Las Vegas Raiders vs New Orleans Saints prediction: Saints 23, Raiders 20; best bet is Pass

New Orleans is projected to beat Las Vegas 23-20 in Week 3. Read the injury outlook and why the supplied spread and total are both a Pass.

Read prediction
NFL PicksSep 27, 2026, 9:02 AM EDT

Minnesota Vikings vs Tampa Bay Buccaneers prediction: Vikings 23, Buccaneers 20

Minnesota gets a narrow 23-20 forecast against Tampa Bay. Our analysis explains why Vikings -1 and the 42.5 total are both passes.

Read prediction
NFL PicksSep 27, 2026, 8:57 AM EDT

Arizona Cardinals vs San Francisco 49ers prediction: 49ers 27, Cardinals 20

San Francisco is projected to beat Arizona 27-20 on September 27, 2026. Injury concerns leave the spread and total as Pass recommendations.

Read prediction
NFL PicksSep 27, 2026, 7:38 AM EDT

Seattle Seahawks vs Washington Commanders prediction: Seattle wins, spread and total are passes

Seattle is projected to beat Washington 23-16 in Week 3. Quarterback availability favors the Seahawks, but the spread and total are passes.

Read prediction
NFL PicksSep 27, 2026, 7:34 AM EDT

Tennessee Titans vs New York Giants prediction: New York wins narrowly, best bet is Pass

Our Giants vs Titans forecast is New York 20, Tennessee 17. See why Giants -2.5 and the 37.5 total both remain a Pass.

Read prediction
NFL PicksSep 27, 2026, 7:30 AM EDT

Cincinnati Bengals vs Pittsburgh Steelers prediction: Bengals win, betting markets are a Pass

Our Bengals vs Steelers forecast is Cincinnati 23, Pittsburgh 17. Cincinnati's defense drives the pick, but the spread and total are both a Pass.

Read prediction
NFL PicksSep 27, 2026, 7:26 AM EDT

Kansas City Chiefs vs Miami Dolphins prediction, odds and best bet for September 27, 2026

Chiefs vs Dolphins prediction: Kansas City wins 27-17, but Chiefs -10 and the 45.5 total are both passes at the supplied SportsJaw prices.

Read prediction