San Francisco 49ers vs
Arizona CardinalsPredictions & Preview

NFC West Showdown: San Francisco 49ers to Take on Arizona Cardinals in Week 18 Matchup at State Farm Stadium

In a non-playoff matchup between NFC West teams, the San Francisco 49ers (6-10) will take on the Arizona Cardinals (7-9) at State Farm Stadium. The Cardinals narrowly defeated the 49ers earlier this season with a score of 24-23. Despite missing the playoffs, both teams are looking to end the season on a high note. The 49ers will be without Brock Purdy for Week 18. Arizona is the betting favorite, opening at -4 and with the current line at Arizona -4.5.

Betting Odds

• Moneyline: 49ers +185 | Cardinals -220
• Spread: 49ers +4.5 (-110) | Cardinals -4.5 (-110)
• Total: Over/Under 43 (-110)
• Based on the moneyline, the implied probability that Arizona will win straight-up is 69%.

San Francisco vs Arizona Stats

San Francisco 49ers

The San Francisco 49ers have had a disappointing season, with a 6-10 record and a recent tough loss to the Detroit Lions. Despite ranking well in offensive statistics, such as total yards and passing yards per game, inconsistencies have plagued the team. Quarterback Brock Purdy has put up impressive numbers but also has struggled with interceptions. The ground game led by Jordan Mason has been solid. Defensively, the team has underperformed, although Nick Bosa's nine sacks have been a bright spot. The team is currently ranked 19th in power rankings, with a 14th ranking in offense and a 20th ranking in defense. Looking for sports wagering options? Consider checking out the best sports betting promos.

Arizona Cardinals Analysis

The Arizona Cardinals started the season strong but have struggled in their most recent games, losing five out of their last six. Their offense ranks 11th in total yards per game, with a strong ground game ranking 7th. Kyler Murray has had a successful season, throwing for over 3,600 yards and running for 550. James Conner has been a reliable running back, rushing for over 1,000 yards. Rookie tight end Trey McBride and first-round pick Marvin Harrison Jr. have been standouts in the passing game. Defensively, the Cardinals rank 18th in total yards against per game. Budda Baker has been a key player on defense. The Cardinals have a power ranking of 14 and are ranked 15th for offense and 14th for defense. They have a 7-9 overall record. Consider using our top NFL handicappers for help with your pro football betting this season.

49ers Face Injuries but Show Betting Potential against Cardinals

The San Francisco 49ers have officially announced that quarterback Brock Purdy will not be available for the upcoming game, with Josh Dobbs stepping in. Additionally, key players such as wide receiver Deebo Samuel have been ruled out, while tight end George Kittle is listed as questionable. Despite the significant number of injuries, the betting odds have shifted in favor of the Arizona Cardinals. However, there appears to be potential line value in favor of the 49ers. While Arizona is rightfully favored, they will be up against a capable backup quarterback in Dobbs, who previously played for them. The Cardinals' pass rush is considered weak, which could give Dobbs and other talented 49ers backups an opportunity to perform well and maintain competitiveness in the game.

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