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  1. Home
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  3. San Francisco 49ers vs Arizona Cardinals
Sun 4:05 PM ET
San Francisco 49ers logo
San Francisco
49ers45
10-3
versus
Arizona Cardinals logo
Arizona
Cardinals29
3-10
Final
Team1234T
San Francisco 49ers147141045
Arizona Cardinals7631329
NFL · San Francisco 49ers at Arizona Cardinals

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Arizona Cardinals Take on 49ers in NFC West Showdown

Game time: December 17, 2023 at 4:05 PM ET

Venue: State Farm Stadium — Glendale, AZ

Article updated Dec 8, 1:35 AM EST

Published by SportsJaw Editorial Team

This Sunday the Arizona Cardinals are looking to upset the division-winning San Francisco 49ers in an important NFC West showdown. The competition between the division rivals

Game outlook

This Sunday the Arizona Cardinals are looking to upset the division-winning San Francisco 49ers in an important NFC West showdown. The competition between the division rivals has become more compelling as the Cardinals hope to gain momentum off their win prior to the bye week while the 49ers look to extend their five game winning streak. It will be a battle of wills in a season where any team can grab a win on any given Sunday, so fans be sure to tune in as these two powerhouses fight it out. With the NFL season winding down, NFL predictions can help fans know who to put their money on.

Betting Odds

Moneyline: 49ers -850 | Cardinals +600

Spread: 49ers -12.5 (-110) | Cardinals +12.5 (-110)

Total: Over/Under 47.5 (-110)

Based on the moneyline, the implied probability that San Francisco will win straight-up is 89%.

San Francisco 49ers

The 49ers are currently on a 5-game winning streak and appear to be in the driver's seat to get the No. 1 seed in the NFC. They have one of the most favorable schedules closing out the season and have won 3 consecutive road games. Their talented and deep squad has created an impressive offense, ranking second in the league in yards and first in yards per play, to go along with a top-ten defense. The San Francisco 49ers are currently enjoying a 10-3 season, making them top contenders for the number one seed in the NFC. They boast the third-best offense in the league, averaging 29.33 points per game, and the second-best defense, allowing 15.75 points, as well as one of the most favorable schedules for the end of the season. The 49ers have consistently won the last five games, including three road matches, with a talented personnel and great depth. The offensive attack has performed well, ranking second in the league for total yards and first for yards per play, while the defense is ranked amongst the top ten teams in nearly all categories.

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Arizona Cardinals Analysis

Nine players are ruled out and 8 are questionable ahead of their home game against San Francisco, while Kyler Murray makes his return and James Conner continues to have a strong season. The Cardinals are struggling and have a single win against the NFC West this year, leading to serious concerns surrounding the best path forward for the franchise.

49ers Poised to Cover Spread in Fourth Straight Game Against Cardinals

The 49ers have been effective in defeating opponents by double-digits for several games and are in a position to extend this pattern with a cover. The Cardinals tend to rely heavily on their ground game, however, the 49ers defense presents a difficulty in gaining traction for such an approach. Purdy and his passing game, along with the contribution from CMC, will support the effort to create potentially high scoring results. The 49ers have shown superior performance in recent matchups and these successes can be expected to continue under favorable indoor conditions. In the series, the 49ers have covered the spread in three consecutive games, in addition to two games of their previous three.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#SanFrancisco49ers#ArizonaCardinals

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw 49ers vs Cardinals archived game preview contains historical odds and availability that may no longer be current. View history of past 49ers vs Cardinals matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · San Francisco 49ers-700 → -750Moved
  • Moneyline · Arizona Cardinals+500 → +525Moved
  • Spread · San Francisco 49ers-13.5 (-110) → -12.25 (-110)Moved
  • Spread · Arizona Cardinals+13.5 (-110) → +12.25 (-110)Moved
  • Total · Over46.5 (-110) → 48 (-110)Moved
  • Total · Under46.5 (-110) → 48 (-110)Moved

ATS and O/U trends

San Francisco 49ers
10-3 matchup record · 5-5-0 ATS · 5-4-1 O/U
Last 10 completed games on file
Arizona Cardinals
3-10 matchup record · 4-6-0 ATS · 5-5-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2023-12-08T06:35:55.576Z). Availability may have changed; review the cited sources.

Nine players are ruled out and 8 are questionable ahead of their home game against San Francisco, while Kyler Murray makes his return and James Conner continues to have a strong season. The Cardinals are struggling and have a single win against the NFC West this year, leading to serious concerns surrounding the best path forward for the franchise.

Recent head-to-head

  • 2023-10-01Arizona Cardinals 16 · San Francisco 49ers 35
  • 2023-01-08Arizona Cardinals 13 · San Francisco 49ers 38
  • 2022-11-21San Francisco 49ers 38 · Arizona Cardinals 10
Final result

Matchup pick recap

San Francisco 49ers defeated Arizona Cardinals 45-29

San Francisco 49ers defeated Arizona Cardinals 45-29 on December 17, 2023, a 16-point decision in the series. San Francisco 49ers' strongest period was the 3rd quarter, when it outscored its opponent 14-3. Against SportsJaw's recorded San Francisco 49ers -12.25 (-110) spread, San Francisco 49ers covered, while the 74 combined points finished over the recorded total of 48.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • 1735203231Spread · San Francisco 49ers -12 (-110)Win
  • Drew_WestcottSpread · San Francisco 49ers +12 (-110)Win
  • UncledavidSpread · San Francisco 49ers +12 (-110)Win
  • RainmanSpread · San Francisco 49ers -12 (-110)Win
  • Steve512Spread · Arizona Cardinals +12 (-110)Loss
  • DemarcusBryantTotal · Under 48.5 (-110)Loss
  • TgodfreyTotal · Under 48.5 (-110)Loss
  • Roderick806Total · Under 48.5 (-110)Loss
  • WarbuczSpread · San Francisco 49ers -12 (-110)Win
  • EmcTotal · Over 48.5 (-110)Win
  • KingjamesTotal · Under 48.5 (-110)Loss
  • JoeyBergSpread · San Francisco 49ers -12 (-110)Win
  • MookiebetsSpread · San Francisco 49ers -12 (-110)Win
  • MauriceJonesSpread · Arizona Cardinals +12 (-110)Loss
  • CoversSpread · San Francisco 49ers -12 (-110)Win
  • Miamimike
Spread · San Francisco 49ers -12 (-110)
Win
  • RcollinsSpread · San Francisco 49ers -12 (-110)Win
  • MickeytSpread · Arizona Cardinals +12 (-110)Loss
  • SimonsaysSpread · San Francisco 49ers -12 (-110)Win
  • CoolioSpread · Arizona Cardinals +12 (-110)Loss
  • CoolioTotal · Under 48.5 (-110)Loss
  • OddssharkSpread · Arizona Cardinals +12 (-110)Loss
  • Mr_BiggsMoneyline · San Francisco 49ers -800Win
  • HitmanhartTotal · Over 48.5 (-110)Win
  • HitmanhartSpread · San Francisco 49ers -12 (-110)Win
  • IrishblueSpread · San Francisco 49ers -12 (-110)Win