Arizona Cardinals versus San Francisco 49ers Head-to-head history

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Sept 27, 2026	Score	Moneyline	Spread	Game total
Arizona CardinalsARI	30	+303 L	+7.5 (-110) W	O 48.5 (-110) W U 48.5 (-108) L
San Francisco 49ersSF	36	-380 W	-7.5 (-110) L

San Francisco 49ers defeated Arizona Cardinals 36-30

San Francisco 49ers defeated Arizona Cardinals 36-30 on September 27, 2026, a 6-point decision in the series. San Francisco 49ers' strongest period was the 1st quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded Arizona Cardinals +7.5 (-110) spread, Arizona Cardinals covered, while the 66 combined points finished over the recorded total of 48.5.

Team	1	2	3	4	T
ARI	0	6	7	17	30
SF	7	10	6	13	36

Nov 16, 2025	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	41	-190 W	-3.5 (-110) W	O 48.5 (-110) W U 48.5 (-110) L
Arizona CardinalsARI	22	+160 L	+3.5 (-110) L

San Francisco 49ers defeated Arizona Cardinals 41-22

San Francisco 49ers defeated Arizona Cardinals 41-22 on November 16, 2025, a 19-point decision in the series. San Francisco 49ers' strongest period was the 3rd quarter, when it outscored its opponent 10-0. Against SportsJaw's recorded San Francisco 49ers -3.5 (-110) spread, San Francisco 49ers covered, while the 63 combined points finished over the recorded total of 48.5.

Team	1	2	3	4	T
SF	13	12	10	6	41
ARI	7	3	0	12	22

Sept 21, 2025	Score	Moneyline	Spread	Game total
Arizona CardinalsARI	15	+105 L	+1.5 (-110) W	O 44.5 (-110) L U 44.5 (-110) W
San Francisco 49ersSF	16	-125 W	-1.5 (-110) L

San Francisco 49ers defeated Arizona Cardinals 16-15

San Francisco 49ers defeated Arizona Cardinals 16-15 on September 21, 2025, a 1-point decision in the series. San Francisco 49ers' strongest period was the 2nd quarter, when it outscored its opponent 6-3. Against SportsJaw's recorded Arizona Cardinals +1.5 (-110) spread, Arizona Cardinals covered, while the 31 combined points finished under the recorded total of 44.5.

Team	1	2	3	4	T
ARI	0	3	3	9	15
SF	0	6	0	10	16

Jan 5, 2025	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	24	+195 L	+5 (-110) L	O 43 (-110) W U 43 (-110) L
Arizona CardinalsARI	47	-225 W	-5 (-110) W

Oct 6, 2024	Score	Moneyline	Spread	Game total
Arizona CardinalsARI	24	+285 W	+7.5 (-110) W	O 49 (-110) L U 49 (-110) W
San Francisco 49ersSF	23	-360 L	-7.5 (-110) L

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1CoversWeighted grade67+$463 · 10 picks7–2 W–L · 77.8%21707662905Weighted grade61+$2,952 · 5 picks4–1 W–L · 80.0%3CoolioWeighted grade56+$136 · 12 picks7–5 W–L · 58.3%

RankHandicapperGradeProfit

4Miamimike4–0 W–L · 100.0%54+$2,3645JoeyBerg4–0 W–L · 100.0%51+$2,0006Tpham3–2 W–L · 60.0%50+$3647Rainman3–1 W–L · 75.0%49+$1,3188Hitmanhart2–2 W–L · 50.0%47+$5689Mackintosh3–0 W–L · 100.0%45+$2,72710Mr_Biggs4–0 W–L · 100.0%43+$1,59411Uncledavid3–0 W–L · 100.0%41+$1,81812Roderick8062–2 W–L · 50.0%41+$26413Captainobvious4–4 W–L · 50.0%40-$4014Sfdan2–0 W–L · 100.0%39+$1,40915Rcollins3–0 W–L · 100.0%39+$79516Emc3–3 W–L · 50.0%39+$35417Tbone913–0 W–L · 100.0%38+$1,65918Oddsshark9–9 W–L · 50.0%38-$10519Steveh2–0 W–L · 100.0%36+$1,15920Irishblue2–0 W–L · 100.0%36+$1,000

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.