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  1. Home
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  3. Arizona Cardinals vs San Francisco 49ers
Sun 4:25 PM ET
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San Francisco 49ers logo
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Arizona Cardinals0106016
San Francisco 49ers71401435
NFL · Arizona Cardinals at San Francisco 49ers

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49ers Look to Undefeated Season as They Take on Struggling Cardinals in Pivotal NFC West Showdown

Game time: October 1, 2023 at 4:25 PM ET

Venue: Levi's Stadium — Santa Clara, CA

Article updated Sep 22, 2:35 AM EDT

Published by SportsJaw Editorial Team

5, while the over/under is 46.5. The Arizona Cardinals will be travelling to San Francisco on Sunday to face the first-place 49ers in an important NFC West showdown. The

Game outlook

5, while the over/under is 46.5. The Arizona Cardinals will be travelling to San Francisco on Sunday to face the first-place 49ers in an important NFC West showdown. The Cardinals will be building off their recent victory over the Cowboys, while the 49ers remain unbeaten in the league this season. Kicking off at 4:25 PM EST, the 49ers are currently favored to win, with a line of -14.5 and an over/under of 46.5 points set.

Game Info

When: Sunday, 10/1/2023 @ 4:25pm EST

Where: Levi's Stadium Stadium Cardinals vs 49ers Betting Odds Moneyline: Cardinals +600 | 49ers -900

Spread: Cardinals +14 (-110) | 49ers -14 (-110)

Total: Over/Under 44 (-110)

Based on the moneyline, the implied probability that San Francisco will win straight-up is 90%.

Arizona Cardinals

The Cardinals have won their first game under head coach Jonathan Gannon, with quarterback Joshua Dobbs at the helm along with running back James Connor and wide receivier Marquis Brown They demonstrated impressive offensive play, with 400 yards in total offense and no turnovers Defensively, the Cardinals allowed 416 yards of total offense and had one interception The Cardinals are ranked 18th in offense (22.00 points scored per game) and 26th in defense (allowing an average of 25.50 points against them per game) Despite being 1-2, the Cardinals are 3-0 ATS (against the spread) The Cardinals are 7th in the NFL in turnover differential and have been penalized an average of 29 times per game (29th in the NFL)

21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

San Francisco 49ers Analysis

The San Francisco 49ers and quarterback Brock Purdy stayed undefeated with a 30-12 win over the Giants. Purdy finished the game 25-of-37 for 310 yards and two touchdowns with no interceptions. The defense held the Giants to just 151 yards of total offense and forced one turnover. The 49ers come in with the fourth-ranked offense in the NFL and third in the league in total defense. Joey Bosa earned his first sack of the season, which will help the 49ers' 20th ranking in sacks. The Niners are third in the NFL in turnover differential. The 49ers have been plagued by penalties, ranking 26th in the league in penalty per game. San Francisco has a power ranking of 1 and are #4 for offense, #2 for defense and 3-0 (2-1 ATS) overall. Arizona has gone 2-1 (2-1 ATS) in their last 3 matchups against San Francisco.

49ers Poised For Triumph Over Struggling Cardinals With Advantageous Ground Attack and Defensive Line Strength

The 49ers boast the third-best ground attack in the NFL, up against a Cardinals team that is ranked 26th against the run. This could give the 49ers an advantage in the passing attack, allowing QB Purdy to play easily. The Cardinals had some success in their last game, slowing down the Cowboys' pass rush with a physical running game. However, SF is third in the league in stopping the run, meaning the Cardinals may struggle to use this same formula for success. QB Dobbs may face difficulty from the Niners' front four, with Bosa possibly making a backfield appearance during the game. This match-up may turn into a one-sided affair, with the Niners possessing an advantageous ground attack and a strong defensive line. Expect a win for SF and take the spread of -14.

Written by Steved Published on 09/28/2023 Category: NFL Picks

About the Author: I apply a behind the scenes mix of technical analyze of stats, real-time news, and fundamental analysis that helps spot advantages to give me and my clients the edge.

SportsJawGame Predictions
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Unavailable for this preview

Projected winnerUnavailableConfidencelow
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#ArizonaCardinals#SanFrancisco49ers

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Cardinals vs 49ers archived game preview contains historical odds and availability that may no longer be current. View history of past Cardinals vs 49ers matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Arizona Cardinals+625 → +700Moved
  • Moneyline · San Francisco 49ers-950 → -1,100Moved
  • Spread · Arizona Cardinals+14.25 (-110) → +15 (-110)Moved
  • Spread · San Francisco 49ers-14.25 (-110) → -15 (-110)Moved
  • Total · Over41 (-110) → 44 (-110)Moved
  • Total · Under41 (-110) → 44 (-110)Moved

ATS and O/U trends

Arizona Cardinals
1-2 matchup record · 6-4-0 ATS · 6-4-0 O/U
Last 10 completed games on file
San Francisco 49ers
3-0 matchup record · 7-2-1 ATS · 5-5-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2023-09-22T06:35:49.736Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2023-01-08Arizona Cardinals 13 · San Francisco 49ers 38
  • 2022-11-21San Francisco 49ers 38 · Arizona Cardinals 10
Final result

Matchup pick recap

San Francisco 49ers defeated Arizona Cardinals 35-16

San Francisco 49ers defeated Arizona Cardinals 35-16 on October 1, 2023, a 19-point decision in the series. San Francisco 49ers' strongest period was the 4th quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Arizona Cardinals +15 (-110) spread, San Francisco 49ers covered, while the 51 combined points finished over the recorded total of 44.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • BjenkinsSpread · San Francisco 49ers -14.5 (-110)Win
  • MackintoshSpread · San Francisco 49ers -14.5 (-110)Win
  • FlyigglesflySpread · Arizona Cardinals +14.5 (-110)Loss
  • StevehSpread · San Francisco 49ers -14.5 (-110)Win
  • JackCohenTotal · Over 41 (-110)Win
  • DerekFisherSpread · Arizona Cardinals +14.5 (-110)Loss
  • Lockpicker69Spread · San Francisco 49ers -14.5 (-110)Win
  • DrpaulSpread · Arizona Cardinals +14.5 (-110)Loss
  • Roderick806Total · Over 41 (-110)Win
  • AdrianMariucciSpread · San Francisco 49ers -14.5 (-110)Win
  • EmcSpread · Arizona Cardinals +14 (-110)Loss
  • TphamSpread · San Francisco 49ers -14 (-110)Win
  • JamescashiolaSpread · San Francisco 49ers -14 (-110)Win
  • 1707662905Spread · San Francisco 49ers -14 (-110)Win
  • MaddogSpread · Arizona Cardinals +14 (-110)Loss
ryry663
Moneyline · San Francisco 49ers -900
Win
  • AliencreationSpread · Arizona Cardinals +14 (-110)Loss
  • CoversSpread · San Francisco 49ers -14 (-110)Win
  • CoolioSpread · San Francisco 49ers -14 (-110)Win
  • CoolioTotal · Under 43.5 (-110)Loss
  • OddssharkSpread · San Francisco 49ers -14 (-110)Win
  • JohnTharpMoneyline · San Francisco 49ers -950Win
  • Mr_BiggsMoneyline · San Francisco 49ers -950Win