Clemson Tigers versus Louisville Cardinals Head-to-head history

Scores, recaps and recorded betting results from the five most recent meetings in SportsJaw history.

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Nov 14, 2025	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	20	+105 W	+1.5 (-110) W	O 51 (-110) L U 51 (-110) W
Louisville CardinalsLOUISV	19	-125 L	-1.5 (-110) L	O 51 (-110) L U 51 (-110) W

Clemson Tigers defeated Louisville Cardinals 20-19

Clemson Tigers defeated Louisville Cardinals 20-19 on November 14, 2025, a 1-point decision in the series. Clemson Tigers' strongest period was the 4th quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded Clemson Tigers +1.5 (-110) spread, Clemson Tigers covered, while the 39 combined points finished under the recorded total of 51.

Team	1	2	3	4	T
Clemson Tigers	3	7	3	7	20
Louisville Cardinals	3	6	10	0	19

Nov 2, 2024	Score	Moneyline	Spread	Game total
Louisville CardinalsLOUISV	33	+330 W	+11 (-110) W	O 62.5 (-110) L U 62.5 (-110) W
Clemson TigersCLEM	21	-420 L	-11 (-110) L	O 62.5 (-110) L U 62.5 (-110) W

Louisville Cardinals defeated Clemson Tigers 33-21

Team	1	2	3	4	T
Louisville Cardinals	3	14	9	7	33
Clemson Tigers	7	0	0	14	21

Nov 12, 2022	Score	Moneyline	Spread	Game total
Louisville CardinalsLOUISV	16	+219 L	+7 (-110) L	O 52 (-110) L U 52 (-110) W
Clemson TigersCLEM	31	-268 W	-7 (-110) W	O 52 (-110) L U 52 (-110) W

Clemson Tigers defeated Louisville Cardinals 31-16

Team	1	2	3	4	T
Louisville Cardinals	0	7	3	6	16
Clemson Tigers	10	7	7	7	31

Oct 19, 2019	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	45	-2600 W	-24.5 (-110) W	O 62 (-110) L U 62 (-110) W
Louisville CardinalsLOUISV	10	+1190 L	+24.5 (-110) L	O 62 (-110) L U 62 (-110) W

Nov 6, 2021	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	30	-177 W	-3.5 (-110) W	O 46.5 (-110) W U 46.5 (-110) L
Louisville CardinalsLOUISV	24	+156 L	+3.5 (-110) L	O 46.5 (-110) W U 46.5 (-110) L