Clemson Tigers versus Louisville Cardinals Head-to-head history

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Nov 14, 2025	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	20	+105 W	+1.5 (-110) W	O 51 (-110) L U 51 (-110) W
Louisville CardinalsLOUISV	19	-125 L	-1.5 (-110) L

Clemson Tigers defeated Louisville Cardinals 20-19

Team	1	2	3	4	T
CLEM	3	7	3	7	20
LOUISV	3	6	10	0	19

Nov 2, 2024	Score	Moneyline	Spread	Game total
Louisville CardinalsLOUISV	33	+330 W	+11 (-110) W	O 62.5 (-110) L U 62.5 (-110) W
Clemson TigersCLEM	21	-420 L	-11 (-110) L

Louisville Cardinals defeated Clemson Tigers 33-21

Team	1	2	3	4	T
LOUISV	3	14	9	7	33
CLEM	7	0	0	14	21

Nov 12, 2022	Score	Moneyline	Spread	Game total
Louisville CardinalsLOUISV	16	+219 L	+7 (-110) L	O 52 (-110) L U 52 (-110) W
Clemson TigersCLEM	31	-268 W	-7 (-110) W

Clemson Tigers defeated Louisville Cardinals 31-16

Team	1	2	3	4	T
LOUISV	0	7	3	6	16
CLEM	10	7	7	7	31

Nov 6, 2021	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	30	-177 W	-3.5 (-110) W	O 46.5 (-110) W U 46.5 (-110) L
Louisville CardinalsLOUISV	24	+156 L	+3.5 (-110) L

Oct 19, 2019	Score	Moneyline	Spread	Game total
Clemson TigersCLEM	45	-2600 W	-24.5 (-110) W	O 62 (-110) L U 62 (-110) W
Louisville CardinalsLOUISV	10	+1190 L	+24.5 (-110) L

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1DrfeelgoodWeighted grade31+$909 · 1 picks1–0 W–L · 100.0%2OddssharkWeighted grade29+$172 · 4 picks3–1 W–L · 75.0%3AdrianMariucciWeighted grade27+$909 · 1 picks1–0 W–L · 100.0%

RankHandicapperGradeProfit

4Ironcladlocks1–0 W–L · 100.0%27+$9095Jtpham1–0 W–L · 100.0%25+$9096Rcobbett222–0 W–L · 100.0%25+$1477Jamescashiola1–0 W–L · 100.0%23+$9098Eljefe1–0 W–L · 100.0%22+$909917352032311–0 W–L · 100.0%21+$90910Vfernandez1–0 W–L · 100.0%21+$90911Gsimms1–0 W–L · 100.0%20+$90912Hitmanhart1–0 W–L · 100.0%20+$90913Irishblue1–0 W–L · 100.0%20+$22714JackCohen1–0 W–L · 100.0%19+$90915Mtgoldstein1–0 W–L · 100.0%19+$22716Randy541–0 W–L · 100.0%17+$90917Amp22231–0 W–L · 100.0%17+$10018Docthizz1–1 W–L · 50.0%17-$6319DerekFisher0–1 W–L · 0.0%16-$10020Tbone911–0 W–L · 100.0%15+$909

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.