Florida Panthers vs Pittsburgh Penguins Predictions Today
Pittsburgh is projected to beat Florida, Penguins 4, Panthers 3, with Florida’s road back-to-back and Jacob Markstrom’s injury providing the strongest matchup reason. Brady Tkachuk’s scoring surge makes the Panthers a dangerous opponent, keeping confidence low. Pittsburgh’s -112 moneyline does not offer a demonstrated betting edge, and neither the puck line nor total warrants an official wager. SportsJaw’s best bet is Pass.
Florida Panthers vs Pittsburgh Penguins prediction and best bet
Pittsburgh is the pick in a close game. Florida faces its second road game in two nights after losing 5-1 at Ottawa, and Markstrom’s absence adds uncertainty in goal. Those circumstances give the Penguins a slight edge in this October 22 NHL matchup.
The distinction is between picking a winner and paying for that outcome. Pittsburgh is favored at -120, but the case rests heavily on Florida’s difficulties rather than a proven Penguins advantage. The official SportsJaw wager is Pass, with both the puck line and total evaluated separately below.
Odds, game time and how to watch
Game: Florida Panthers at Pittsburgh Penguins, 2026-27 NHL season.
Time: Thursday, October 22, 2026, at 7 p.m. ET.
Venue: PPG Paints Arena.
Florida record: 5-3-2 after an October 21 loss at Ottawa ended a three-game winning streak.
SportsJaw moneyline: Florida +100; Pittsburgh -120.
SportsJaw puck line: Florida +1.5 (-235); Pittsburgh -1.5 (+210). Total: Over 6.5 (-133); Under 6.5 (+117).
Florida Panthers outlook
Florida’s best offensive argument is Brady Tkachuk. He scored in the Ottawa loss, and the Panthers’ recap credited him with seven goals over his previous four games. That finishing streak gives Florida a credible route to an outright win even after Wednesday’s setback.

