Jacksonville Jaguars versus San Francisco 49ers Head-to-head history

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Sept 28, 2025	Score	Moneyline	Spread	Game total
Jacksonville JaguarsJAC	26	+145 W	+3 (-110) W	O 46 (-110) W U 46 (-110) L
San Francisco 49ersSF	21	-165 L	-3 (-110) L

Jacksonville Jaguars defeated San Francisco 49ers 26-21

Team	1	2	3	4	T
JAC	0	17	9	0	26
SF	3	3	8	7	21

Nov 12, 2023	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	34	-170 W	-3 (-110) W	O 44.5 (-110) L U 44.5 (-110) W
Jacksonville JaguarsJAC	3	+150 L	+3 (-110) L

San Francisco 49ers defeated Jacksonville Jaguars 34-3

Team	1	2	3	4	T
SF	10	3	14	7	34
JAC	0	3	0	0	3

Nov 21, 2021	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	30	-275 W	-6.5 (-110) W	O 45.5 (-110) L U 45.5 (-110) W
Jacksonville JaguarsJAC	10	+230 L	+6.5 (-110) L

San Francisco 49ers defeated Jacksonville Jaguars 30-10

Team	1	2	3	4	T
SF	3	17	7	3	30
JAC	0	3	0	7	10

Dec 24, 2017	Score	Moneyline	Spread	Game total
Jacksonville JaguarsJAC	33	— —	-4 (-110) L	O 43 (-110) W U 43 (-110) L
San Francisco 49ersSF	44	— —	+4 (-110) W

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1VegaspatWeighted grade31+$909 · 1 picks1–0 W–L · 100.0%2ThetotalerWeighted grade29+$500 · 1 picks1–0 W–L · 100.0%3AveragejoeWeighted grade27+$909 · 1 picks1–0 W–L · 100.0%

RankHandicapperGradeProfit

4Georgew1–0 W–L · 100.0%27+$9095MauriceJones1–0 W–L · 100.0%27+$5006Emc1–0 W–L · 100.0%26+$5007Teddy7181–0 W–L · 100.0%25+$9098Rainman1–0 W–L · 100.0%25+$2509Toufff1–0 W–L · 100.0%24+$58810Ua20041–0 W–L · 100.0%24+$50011Mikehuff1–0 W–L · 100.0%24+$25012Covers2–0 W–L · 100.0%24+$19113Shoulderfat1–0 W–L · 100.0%23+$25014ICIcar1–0 W–L · 100.0%22+$50015Nutinbutlocks1–0 W–L · 100.0%22+$25016Coolio2–2 W–L · 50.0%22-$1917LeBronStopper2–0 W–L · 100.0%20+$20018Douwanna1–0 W–L · 100.0%19+$45519Doclocks1–0 W–L · 100.0%18+$25020Flaboy9541–0 W–L · 100.0%18+$250

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.