Indianapolis Colts versus San Francisco 49ers Head-to-head history

Scores, recaps and recorded betting results from the five most recent meetings in SportsJaw history.

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Dec 22, 2025	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	48	-220 W	-4.25 (-110) W	O 46.5 (-110) W U 46.5 (-110) L
Indianapolis ColtsIND	27	+185 L	+4.25 (-110) L	O 46.5 (-110) W U 46.5 (-110) L

San Francisco 49ers defeated Indianapolis Colts 48-27

San Francisco 49ers defeated Indianapolis Colts 48-27 on December 22, 2025, a 21-point decision in the series. San Francisco 49ers' strongest period was the 1st quarter, when it outscored its opponent 14-7. Against SportsJaw's recorded San Francisco 49ers -4.25 (-110) spread, San Francisco 49ers covered, while the 75 combined points finished over the recorded total of 46.5.

Team	1	2	3	4	T
San Francisco 49ers	14	10	10	14	48
Indianapolis Colts	7	10	3	7	27

Oct 24, 2021	Score	Moneyline	Spread	Game total
Indianapolis ColtsIND	30	+148 W	+3.5 (-110) W	O 41.5 (-110) W U 41.5 (-110) L
San Francisco 49ersSF	18	-170 L	-3.5 (-110) L	O 41.5 (-110) W U 41.5 (-110) L

Indianapolis Colts defeated San Francisco 49ers 30-18

Team	1	2	3	4	T
Indianapolis Colts	7	6	7	10	30
San Francisco 49ers	12	0	0	6	18

Aug 25, 2018	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	17	— —	+0 (-110) L	O 42 (-110) L U 42 (-110) W
Indianapolis ColtsIND	23	— —	+0 (-110) W	O 42 (-110) L U 42 (-110) W

Indianapolis Colts defeated San Francisco 49ers 23-17

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

JoeThomasWeighted grade39+$1,159 · 2 picks2–0 W–L · 100.0%2

HopkinspicksWeighted grade38+$1,009 · 2 picks2–0 W–L · 100.0%3

MrshinyWeighted grade32+$967 · 2 picks2–0 W–L · 100.0%

RankHandicapperGradeProfit

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.