Indianapolis Colts versus San Francisco 49ers Head-to-head history

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Dec 22, 2025	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	48	-220 W	-4.25 (-110) W	O 46.5 (-110) W U 46.5 (-110) L
Indianapolis ColtsIND	27	+185 L	+4.25 (-110) L

San Francisco 49ers defeated Indianapolis Colts 48-27

Team	1	2	3	4	T
SF	14	10	10	14	48
IND	7	10	3	7	27

Oct 24, 2021	Score	Moneyline	Spread	Game total
Indianapolis ColtsIND	30	+148 W	+3.5 (-110) W	O 41.5 (-110) W U 41.5 (-110) L
San Francisco 49ersSF	18	-170 L	-3.5 (-110) L

Indianapolis Colts defeated San Francisco 49ers 30-18

Team	1	2	3	4	T
IND	7	6	7	10	30
SF	12	0	0	6	18

Aug 25, 2018	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	17	— —	+0 (-110) L	O 42 (-110) L U 42 (-110) W
Indianapolis ColtsIND	23	— —	+0 (-110) W

Indianapolis Colts defeated San Francisco 49ers 23-17

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1JoeThomasWeighted grade39+$1,159 · 2 picks2–0 W–L · 100.0%2HopkinspicksWeighted grade37+$1,009 · 2 picks2–0 W–L · 100.0%3MrshinyWeighted grade31+$967 · 2 picks2–0 W–L · 100.0%

RankHandicapperGradeProfit

4Moneymouth2–0 W–L · 100.0%30+$1,0095AdrianMariucci1–0 W–L · 100.0%30+$9096Dawhiz1–0 W–L · 100.0%30+$9097Johnmizner1–0 W–L · 100.0%30+$9098Jw1–0 W–L · 100.0%30+$9099Nutinbutlocks1–0 W–L · 100.0%29+$90910Flyigglesfly1–0 W–L · 100.0%28+$90911Jaredkuntz1–0 W–L · 100.0%28+$90912Jtpham1–0 W–L · 100.0%28+$90913Philly2671–0 W–L · 100.0%27+$90914Vfernandez1–0 W–L · 100.0%27+$90915Mr_Biggs1–0 W–L · 100.0%26+$90916Mrmister1–0 W–L · 100.0%25+$90917Fuhq2–1 W–L · 66.7%24+$51818Purpleblood1–0 W–L · 100.0%23+$90919LeBronStopper2–0 W–L · 100.0%20+$27020Vegaspat1–0 W–L · 100.0%17+$500

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.