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NFL picks›Buffalo Bills vs Detroit Lions predictions

BuffaloBillsVSDetroitLions

Upcoming odds, recent results, and verified experts who have performed best when these teams take the field.

Odds & predictions

Upcoming matchups

Sept 17, 2026Thursday @ 8:15PM ET
Detroit LionsSpread +3.5 (-108)Moneyline +160
VS
Buffalo BillsSpread -3.5 (-110)Moneyline -190
Over/Under53.5 (-110)View predictions
Head-to-head history

Past matchups

5 final results in SportsJaw history

Dec 15, 2024
Buffalo Bills48Detroit Lions42Final
Nov 24, 2022
Buffalo Bills28Detroit Lions25Final
Aug 13, 2021
Buffalo Bills16Detroit Lions15Final
Aug 23, 2019
Buffalo Bills24Detroit Lions20Final
Dec 16, 2018

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.

Detroit Lions
13
Buffalo Bills
14
Final
Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

1GeorgewWeighted grade36+$1,409 · 2 picks2CovergirlWeighted grade34+$682 · 2 picks3ThehitmanWeighted grade32+$909 · 1 picks
RankHandicapperGradeProfit
4DemarcusBryant31+$9095Miamimike31+$9096Roycejacobs30+$9097Joem8129+$9098Kentc_29+$9099MauriceJones29+$34110Johnmizner28+$909