| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| San Francisco 49ersSF | 34 | -137 W | -2.5 (-110) W | O 47.5 (-110) W U 47.5 (-110) L |
| New York GiantsNYG | 24 | +118 L | +2.5 (-110) L |
San Francisco 49ers defeated New York Giants 34-24
San Francisco 49ers defeated New York Giants 34-24 on November 2, 2025, a 10-point decision in the series. San Francisco 49ers' strongest period was the 2nd quarter, when it outscored its opponent 10-0. Against SportsJaw's recorded San Francisco 49ers -2.5 (-110) spread, San Francisco 49ers covered, while the 58 combined points finished over the recorded total of 47.5.
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