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  3. New York Giants vs Los Angeles Rams
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Los Angeles Rams777728
NFL · New York Giants at Los Angeles Rams

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Giants vs. Rams: Injury Questions Make Monday Night a Pass

Game time: September 21, 2026 at 8:15 PM ET

Venue: SoFi Stadium — Inglewood, CA

Article updated Sep 19, 12:34 AM EDT

By SportsJaw Editorial Team

Los Angeles is a seven-point favorite, but New York's productive opener and personnel concerns on both teams leave the side and total unresolved.

One week offers an incomplete picture

The New York Giants visit the Los Angeles Rams at SoFi Stadium on Monday, September 21, for Week 2 of the 2026 NFL season. Kickoff is scheduled for 8:15 p.m. ET. New York opened with a 28-20 victory over Dallas; Los Angeles lost 27-7 to San Francisco in Australia.

Jaxson Dart gave the Giants an encouraging start, completing 79.3% of his passes for 230 yards and three touchdowns with a 134.2 passer rating. He also gained 59 rushing yards before kneel-downs. Those numbers support respect for New York's offense, but one game does not establish how it will perform against this Rams defense.

Availability cuts both ways

Aaron Donald said he plans to make his season debut against the Giants after participating in 11-on-11 work during the week. His anticipated availability adds a concern for New York, with tackle Andrew Thomas limited Thursday and Friday by an ankle injury. Donald's stated plan does not establish his eventual workload.

Los Angeles will be without Myles Garrett, who is on injured reserve after knee surgery and will miss at least four games beginning Monday. Puka Nacua, Jordan Whittington and Kamren Kinchens did not practice Friday. Davante Adams returned to full participation after resting Thursday.

The Giants have their own secondary concerns: Paulson Adebo was listed with a knee issue and an IR designation, while Deonte Banks missed Friday's practice with a calf injury after being limited Thursday. The practice reports leave meaningful uncertainty; they do not establish that every non-participant will miss the game.

21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

SportsJaw pick: Pass

SportsJaw lists Los Angeles at -295 moneyline and -7 (-115), with New York at +240 moneyline and +7 (-105). The total is 48, with over and under each priced at -110.

The opening results and injury reports do not establish an edge at those prices. They also leave the scoring case unresolved, so neither total direction warrants a recommendation. Pass, with no winner or score projection.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Pass

Pick on the Total

Published pick: Pass

Sources

  • NFL.comNFL Week 2 injury report: Player statuses for all 16 games
  • Giants.comInjury Report: Statuses for Giants vs. Rams on Monday Night Football
  • Giants.comPlayers to watch in Monday's primetime matchup
#NewYorkGiants#LosAngelesRams

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Written by

SportsJaw Editorial Team

SportsJaw's editorial organization researches matchup data, current odds, injuries and reporting, then validates each published preview against its listed sources and displayed markets.

About our editorial process

SportsJaw Giants vs Rams game preview analysis and predictions incorporate current odds, injury reports, team statistics and market data. Information is updated regularly, but lines and player availability can change. Please confirm current information before wagering. View history of past Giants vs Rams matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · New York Giants+307 → +240Moved
  • Moneyline · Los Angeles Rams-381 → -295Moved
  • Spread · New York Giants+8.5 (-110) → +6.5 (-105)Moved
  • Spread · Los Angeles Rams-8.5 (-110) → -6.5 (-115)Moved
  • Total · Over48.5 (-110) → 47.5 (-108)Moved
  • Total · Under48.5 (-110) → 47.5 (-112)Moved

ATS and O/U trends

New York Giants
1-0 matchup record · 6-4-0 ATS · 8-2-0 O/U
Last 10 completed games on file
Los Angeles Rams
0-1 matchup record · 4-6-0 ATS · 8-2-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2026-09-15T10:10:50.869Z). Availability may have changed; review the cited sources.

Aaron Donald said he plans to make his season debut against the Giants after participating in 11-on-11 work during the week. His anticipated availability adds a concern for New York, with tackle Andrew Thomas limited Thursday and Friday by an ankle injury. Donald's stated plan does not establish his eventual workload.

Los Angeles will be without Myles Garrett, who is on injured reserve after knee surgery and will miss at least four games beginning Monday. Puka Nacua, Jordan Whittington and Kamren Kinchens did not practice Friday. Davante Adams returned to full participation after resting Thursday.

The Giants have their own secondary concerns: Paulson Adebo was listed with a knee issue and an IR designation, while Deonte Banks missed Friday's practice with a calf injury after being limited Thursday. The practice reports leave meaningful uncertainty; they do not establish that every non-participant will miss the game.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Los Angeles Rams defeated New York Giants 28-6

Los Angeles Rams defeated New York Giants 28-6 on September 21, 2026, a 22-point decision in the series. Los Angeles Rams' strongest period was the 1st quarter, when it outscored its opponent 7-0. Against SportsJaw's recorded New York Giants +6.5 (-105) spread, Los Angeles Rams covered, while the 34 combined points finished under the recorded total of 47.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable
  • SpreadPassPass
  • TotalPassPass

Tipster picks

  • DtownsendSpread · New York Giants +7 (-106)Loss
  • PurplebloodSpread · New York Giants +7 (-106)Loss
  • JtmcentireTotal · Under 48.5 (-110)Win
  • JtmcentireSpread · Los Angeles Rams -7 (-114)Win
  • Steve512Total · Under 48.5 (-110)Win
  • WarbuczSpread · Los Angeles Rams -7 (-114)Win
  • PeytoncSpread · New York Giants +7 (-106)Loss
  • DerekFisherTotal · Under 48.5 (-110)Win
  • Sarah_MillerTotal · Over 48.5 (-108)Loss
  • JamescashiolaSpread · Los Angeles Rams +7 (-106)Win
  • TgodfreySpread · Los Angeles Rams -7 (-114)Win
  • MackintoshSpread · New York Giants +7 (-106)Loss
  • MackintoshTotal · Over 48.5 (-108)Loss
  • MikeVargasSpread · New York Giants +7 (-106)Loss
Gsimms
Total · Over 48.5 (-108)
Loss
  • TweiskoffTotal · Over 48.5 (-108)Loss
  • IroncladlocksSpread · Los Angeles Rams +7 (-106)Win
  • Teddy718Spread · New York Giants +7 (-106)Loss
  • SimonsaysSpread · New York Giants +7 (-106)Loss
  • SfdanTotal · Over 48.5 (-108)Loss
  • Roderick806Spread · Los Angeles Rams -7 (-114)Win
  • JoeyBergTotal · Under 48.5 (-110)Win
  • MookiebetsSpread · New York Giants +7 (-106)Loss
  • NutinbutlocksTotal · Over 48.5 (-108)Loss
  • AdrianMariucciSpread · Los Angeles Rams +7 (-106)Win
  • AdrianMariucciTotal · Under 48.5 (-108)Win
  • DawhizSpread · Los Angeles Rams -7 (-114)Win
  • MauriceJonesTotal · Over 48.5 (-108)Loss
  • MiamimikeTotal · Over 48.5 (-108)Loss
  • VegaspatTotal · Over 48.5 (-108)Loss
  • StevedTotal · Over 48.5 (-108)Loss
  • CovergirlSpread · Los Angeles Rams -7 (-115)Win
  • VegaspatSpread · New York Giants +7 (-105)Loss
  • JwSpread · New York Giants +7 (-105)Loss
  • StevehSpread · Los Angeles Rams -7 (-115)Win
  • JackCohenSpread · New York Giants +7 (-105)Loss
  • CovergirlTotal · Over 48.5 (-108)Loss
  • JwTotal · Under 48.5 (-108)Win
  • Mickey619Spread · Los Angeles Rams +7 (-106)Win
  • StevehTotal · Under 48.5 (-112)Win
  • JackCohenTotal · Over 48.5 (-108)Loss
  • GustavosintoSpread · New York Giants +7 (-106)Loss
  • Mickey619Total · Over 48 (-110)Loss
  • GustavosintoTotal · Over 48 (-110)Loss
  • SwamipicksSpread · Los Angeles Rams -7 (-115)Win
  • KingjamesSpread · New York Giants +7 (-105)Loss
  • SwamipicksTotal · Under 48 (-110)Win
  • FlyigglesflyTotal · Under 48 (-110)Win
  • GeorgewTotal · Under 48 (-110)Win
  • KingjamesTotal · Over 48 (-110)Loss
  • JohnnywalkerTotal · Under 48 (-110)Win
  • TphamTotal · Over 48 (-110)Loss
  • MaddogTotal · Under 48 (-110)Win
  • BrycetTotal · Over 48 (-110)Loss
  • Sammy52Total · Under 48 (-110)Win
  • MoneymouthTotal · Over 48 (-110)Loss
  • MtgoldsteinTotal · Under 48 (-110)Win
  • KrockpicksTotal · Over 48 (-110)Loss
  • Novacek84Total · Under 48 (-110)Win
  • Hustle$Total · Over 48 (-110)Loss
  • Altuve27Spread · New York Giants +7 (-110)Loss
  • Sammy52Spread · New York Giants +7 (-110)Loss
  • Novacek84Spread · Los Angeles Rams -7 (-110)Win
  • Philly267Spread · New York Giants +7 (-110)Loss
  • PremierPicksSpread · Los Angeles Rams +7 (-110)Win
  • JoeThomasSpread · Los Angeles Rams -7 (-110)Win
  • BjenkinsTotal · Over 48 (-110)Loss
  • JohnmiznerTotal · Under 48 (-110)Win
  • FlyigglesflySpread · Los Angeles Rams -7 (-110)Win
  • DemarcusBryantSpread · Los Angeles Rams -7 (-110)Win
  • MtgoldsteinSpread · New York Giants +7 (-110)Loss
  • EmcTotal · Under 48 (-110)Win
  • KrockpicksSpread · New York Giants +7 (-110)Loss
  • DoclocksSpread · Los Angeles Rams -7 (-110)Win
  • Altuve27Total · Over 48 (-110)Loss
  • MoneymouthSpread · Los Angeles Rams -7 (-110)Win
  • MiamimikeSpread · Los Angeles Rams -7 (-105)Win
  • BrycetSpread · New York Giants +7 (-115)Loss
  • DtownsendTotal · Over 47.5 (-110)Loss
  • TphamSpread · Los Angeles Rams -7 (-105)Win
  • Tbone91Total · Over 47.5 (-110)Loss
  • JeffjacksonTotal · Under 47.5 (-110)Win
  • JtgarciaTotal · Over 47.5 (-110)Loss
  • DerekFisherSpread · New York Giants +7 (-115)Loss
  • Fisher49Spread · Los Angeles Rams -7 (-105)Win
  • JohnnywalkerSpread · New York Giants +7 (-115)Loss
  • JohnmiznerSpread · Los Angeles Rams -7 (-105)Win
  • Leadpipe_LocksTotal · Over 47.5 (-110)Loss
  • DemarcusBryantTotal · Over 47.5 (-110)Loss
  • ThetotalerTotal · Under 47.5 (-110)Win
  • JtphamTotal · Over 47.5 (-110)Loss
  • MbcSpread · New York Giants +7 (-115)Loss
  • MbcTotal · Over 47.5 (-110)Loss
  • EmcSpread · New York Giants +7 (-115)Loss
  • JoeyBergSpread · Los Angeles Rams -7 (-105)Win
  • NutinbutlocksSpread · Los Angeles Rams -7 (-105)Win
  • Josh720Total · Over 47.5 (-110)Loss
  • TjwinsTotal · Over 47.5 (-110)Loss
  • BluedevilSpread · New York Giants +7 (-115)Loss
  • RoycejacobsSpread · New York Giants +7 (-115)Loss
  • DoclocksTotal · Under 47.5 (-110)Win
  • RcSpread · New York Giants +7 (-115)Loss
  • BadmanSpread · New York Giants +7 (-115)Loss
  • ThinkmakegrowSpread · Los Angeles Rams -7 (-105)Win
  • 1188460207Spread · New York Giants +6.5 (-105)Loss
  • MaddogSpread · New York Giants +6.5 (-105)Loss
  • HitmanhartSpread · Los Angeles Rams -6.5 (-117)Win
  • DengWinsTotal · Over 47.5 (-110)Loss
  • ThetotalerSpread · Los Angeles Rams -6.5 (-117)Win
  • 1118240754Spread · Los Angeles Rams -6.5 (-117)Win
  • Lockpicker69Spread · Los Angeles Rams -6.5 (-117)Win
  • GeorgewSpread · Los Angeles Rams -6.5 (-117)Win
  • MickeytTotal · Under 47.5 (-110)Win
  • MickeytSpread · New York Giants +6.5 (-105)Loss
  • MikehuffSpread · Los Angeles Rams -6.5 (-117)Win
  • JtphamSpread · Los Angeles Rams +6.5 (-105)Win
  • BillywatersSpread · Los Angeles Rams -6.5 (-117)Win
  • StevedSpread · New York Giants +6.5 (-105)Loss
  • GeauxtigersTotal · Under 47.5 (-110)Win
  • Josh720Spread · New York Giants +6.5 (-105)Loss
  • 1707662905Total · Over 47.5 (-110)Loss
  • RainmanTotal · Under 47.5 (-110)Win
  • BluedevilTotal · Over 47.5 (-110)Loss
  • IrishblueTotal · Over 47.5 (-110)Loss
  • Hustle$Spread · Los Angeles Rams -6.5 (-117)Win
  • Joem81Total · Under 47.5 (-110)Win
  • Joem81Spread · New York Giants +6.5 (-105)Loss
  • BookieslayerSpread · Los Angeles Rams -6.5 (-115)Win
  • BookieslayerTotal · Under 47.5 (-110)Win
  • AveragejoeSpread · Los Angeles Rams -6.5 (-115)Win
  • DrfeelgoodTotal · Over 47.5 (-110)Loss
  • DrfeelgoodSpread · Los Angeles Rams -6.5 (-115)Win
  • Philly267Total · Under 47.5 (-110)Win
  • MrpinkSpread · New York Giants +6.5 (-105)Loss
  • MrpinkTotal · Over 47.5 (-110)Loss
  • Tbone91Spread · New York Giants +6.5 (-105)Loss
  • JeffjacksonSpread · Los Angeles Rams +6.5 (-105)Win
  • HitmanhartTotal · Under 47.5 (-110)Win
  • PremierPicksTotal · Over 47.5 (-110)Loss
  • DengWinsSpread · Los Angeles Rams -6.5 (-115)Win
  • RcollinsTotal · Under 47.5 (-110)Win
  • RcollinsSpread · New York Giants +6.5 (-105)Loss
  • JoeThomasTotal · Under 47.5 (-110)Win
  • BjenkinsSpread · Los Angeles Rams -6.5 (-115)Win
  • Leadpipe_LocksSpread · Los Angeles Rams -6.5 (-115)Win
  • UncledavidTotal · Under 47.5 (-110)Win
  • UncledavidSpread · New York Giants +6.5 (-105)Loss
  • Randy54Spread · New York Giants +6.5 (-105)Loss
  • Randy54Total · Under 47.5 (-110)Win
  • GsimmsSpread · Los Angeles Rams -6.5 (-115)Win
  • Lockpicker69Total · Over 47.5 (-110)Loss
  • ThehitmanSpread · New York Giants +6.5 (-105)Loss
  • ThehitmanTotal · Over 47.5 (-110)Loss
  • MikehuffTotal · Over 47.5 (-110)Loss
  • BillywatersTotal · Over 47.5 (-110)Loss
  • DrpaulSpread · New York Giants +6.5 (-105)Loss
  • MrmisterTotal · Over 47.5 (-110)Loss
  • MrmisterSpread · Los Angeles Rams -6.5 (-115)Win
  • EljefeTotal · Under 47.5 (-110)Win
  • EljefeSpread · Los Angeles Rams -6.5 (-115)Win
  • GeauxtigersSpread · Los Angeles Rams -6.5 (-115)Win
  • 1707662905Spread · Los Angeles Rams -6.5 (-115)Win
  • TjwinsSpread · New York Giants +6.5 (-105)Loss
  • RainmanSpread · New York Giants +6.5 (-105)Loss
  • IrishblueSpread · Los Angeles Rams -6.5 (-115)Win
  • ThinkmakegrowTotal · Under 47.5 (-110)Win
  • SJ_3693778eab338a1bSpread · New York Giants +6.5 (-105)Loss
  • SJ_3693778eab338a1bMoneyline · New York Giants +250Loss
  • SJ_3693778eab338a1bTotal · Over 47.5 (-110)Loss
  • SJ_9d6202583c987c76Spread · New York Giants +6.5 (-105)Loss
  • SJ_1022651b9c35fee2Spread · New York Giants +6.5 (-105)Loss
  • KryptonSpread · Los Angeles Rams -6.5 (-115)Win