Seahawks at Cardinals: Quarterback change leaves Seattle a difficult bet
Seattle is favored by four points, but absences at quarterback and right guard complicate its case against an Arizona team with injury concerns of its own.
Seattle enters with two offensive replacements
The Seattle Seahawks visit the Arizona Cardinals on September 20 in Week 2 of the 2026 NFL season. SportsJaw lists Seattle at -205 on the moneyline and -4 (-108), with Arizona at +175 and +4 (-113).
Drew Lock will start for Seattle, with Jalen Milroe backing him up. Sam Darnold is out with a glute injury suffered five snaps into the season-opening 13-10 win over New England. Starting right guard Anthony Bradford is also out with knee and hip injuries, following a Saturday downgrade from questionable.
Those absences create uncertainty about Seattle's offensive execution. They do not, by themselves, establish that Arizona should be favored or that four points offer enough protection to back the Cardinals.
Arizona's injury list limits the counterargument
Arizona will be without cornerback Garrett Williams. Cornerback Max Melton and safety Dadrion Taylor-Demerson are questionable, as are guards Isaac Seumalo and Isaiah Adams and defensive linemen Roy Lopez and Andrew Billings. Questionable designations leave their availability unresolved; they should not be counted as confirmed absences.
Trey McBride, Budda Baker, and Josh Sweat practiced fully Thursday and Friday after Wednesday rest designations. Seattle also has defensive uncertainty, with safety Ty Okada out and Nick Emmanwori questionable. The injury picture offers reasons for caution on both sides.