Ravens vs. Colts: Opening-week questions make this a pass
Baltimore is favored by 3.5 points, but the available evidence does not establish value on either side.
Matchup and market
The Baltimore Ravens visit the Indianapolis Colts at Lucas Oil Stadium on September 13 for their 2026 NFL regular-season opener. Baltimore's preview lists kickoff at 1 p.m.
The Ravens are -175 on the moneyline and -3.5 (-110) against the spread. Indianapolis is +150 on the moneyline and +3.5 (-110). Over 48 and under 48 are each priced at -110. Those prices establish Baltimore as the market favorite, but do not independently justify a winner or projected score.
What the matchup supports
Jonathan Taylor provides a reason to examine Indianapolis closely. According to Baltimore's opponent preview, he led the NFL in carries, rushing touchdowns and yards after contact last season. Ravens defensive tackle Nnamdi Madubuike is out with a neck injury. Those facts make the Colts' rushing attack relevant to the analysis, without establishing how effectively it will perform Sunday.
Baltimore also enters with substantial offensive changes. Declan Doyle begins his first season calling plays, and the offensive starters skipped preseason action. The line has three new starters, including Jovaughn Gwyn and Vega Ioane, who are scheduled to make their first career starts. Jesse Minter makes his Baltimore head-coaching debut.
Indianapolis reports a healthy secondary featuring Sauce Gardner, Charvarius Ward Sr. and Cam Bynum. Baltimore receiver Zay Flowers carries no game injury designation after practicing fully Thursday and Friday. Neither update establishes a decisive passing-game advantage.