| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| San Francisco 49ersSF | 15 | +130 L | +3 (-110) L | O 41 (-110) P U 41 (-110) P |
| Houston TexansHOU | 26 | -160 W | -3 (-110) W |
Houston Texans defeated San Francisco 49ers 26-15
Houston Texans defeated San Francisco 49ers 26-15 on October 26, 2025, a 11-point decision in the series. Houston Texans' strongest period was the 2nd quarter, when it outscored its opponent 13-7. Against SportsJaw's recorded San Francisco 49ers +3 (-110) spread, Houston Texans covered, while the 41 total pushed.
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