Indianapolis Colts versus Los Angeles Chargers Head-to-head history

Oct 19, 2025	Score	Moneyline	Spread	Game total
Indianapolis ColtsIND	38	+125 W	+2.5 (-110) W	O 49 (-110) W U 49 (-110) L
Los Angeles ChargersLAC	24	-142 L	-2.5 (-110) L

Indianapolis Colts defeated Los Angeles Chargers 38-24

Indianapolis Colts defeated Los Angeles Chargers 38-24 on October 19, 2025, a 14-point decision in the series. Indianapolis Colts' strongest period was the 2nd quarter, when it outscored its opponent 17-0. Against SportsJaw's recorded Indianapolis Colts +2.5 (-110) spread, Indianapolis Colts covered, while the 62 combined points finished over the recorded total of 49.