New Orleans Saints versus San Francisco 49ers Head-to-head history

Scores, recaps and recorded betting results from the five most recent meetings in SportsJaw history.

SportsJaw’s stored game records date back to 2015. The news feed shows up to the five most recent completed meetings.

Head-to-head history

Last five meetings

Recent game recaps, recorded odds and betting results

Sept 14, 2025	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	26	-157 W	-3 (-110) W	O 40.5 (-110) W U 40.5 (-110) L
New Orleans SaintsNO	21	+137 L	+3 (-110) L	O 40.5 (-110) W U 40.5 (-110) L

San Francisco 49ers defeated New Orleans Saints 26-21

San Francisco 49ers defeated New Orleans Saints 26-21 on September 14, 2025, a 5-point decision in the series. San Francisco 49ers' strongest period was the 1st quarter, when it outscored its opponent 6-0. Against SportsJaw's recorded San Francisco 49ers -3 (-110) spread, San Francisco 49ers covered, while the 47 combined points finished over the recorded total of 40.5.

Team	1	2	3	4	T
San Francisco 49ers	6	10	3	7	26
New Orleans Saints	0	7	7	7	21

Nov 27, 2022	Score	Moneyline	Spread	Game total
New Orleans SaintsNO	0	+320 L	+8.5 (-110) L	O 43.5 (-110) L U 43.5 (-110) W
San Francisco 49ersSF	13	-400 W	-8.5 (-110) W	O 43.5 (-110) L U 43.5 (-110) W

San Francisco 49ers defeated New Orleans Saints 13-0

Team	1	2	3	4	T
New Orleans Saints	0	0	0	0	0
San Francisco 49ers	3	7	3	0	13

Nov 15, 2020	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	13	+325 L	+10 (-110) L	O 49 (-110) L U 49 (-110) W
New Orleans SaintsNO	27	-425 W	-10 (-110) W	O 49 (-110) L U 49 (-110) W

New Orleans Saints defeated San Francisco 49ers 27-13

Dec 8, 2019	Score	Moneyline	Spread	Game total
San Francisco 49ersSF	48	+102 W	+1.5 (-110) W	O 45 (-110) W U 45 (-110) L
New Orleans SaintsNO	46	-122 L	-1.5 (-110) L	O 45 (-110) W U 45 (-110) L

Verified performance

Experts who know these teams

Weighted grade based on 75% profit from head-to-head bets and 25% from profits earned betting on either team.

CoversWeighted grade31+$291 · 3 picks3–0 W–L · 100.0%2

XyoojsterWeighted grade30+$573 · 2 picks2–0 W–L · 100.0%3

JohnTharpWeighted grade29+$572 · 2 picks2–0 W–L · 100.0%

RankHandicapperGradeProfit

Expert grades weight verified head-to-head profit at 75% and profit on other games involving either team at 25%, with a confidence adjustment until ten qualifying picks are recorded.