Indianapolis Colts vs Washington Commanders Prediction, Odds and Best Bet for Oct. 4, 2026
The Indianapolis Colts will beat the Washington Commanders, Colts 24, Commanders 20, in a low-confidence forecast built around Washington’s personnel absences, including Jayden Daniels. Washington’s run defense and Daniel Jones’ turnovers make the margin uncertain. Neither Colts -4.5 (-110) nor the total of 46.5 (-110) offers a convincing betting edge; the official SportsJaw recommendation is Pass.
Indianapolis Colts vs Washington Commanders prediction and best bet
Indianapolis gets the outright pick because Washington enters without its starting quarterback and several other contributors. That tilts a close forecast toward the Colts, but it does not make their offense a comfortable favorite against this defensive front. The prediction is Colts 24, Commanders 20, with Pass as the best betting decision.
The strongest counterargument is specific: Washington’s run defense can challenge Jonathan Taylor, and Jones has already committed five giveaways through three games. If Indianapolis needs its passing game to recover from stalled rushing attempts, Washington has a credible route to an upset. Those risks keep confidence low and make laying 4.5 points unappealing.
Odds, game time and how to watch
Game time: Sunday, Oct. 4, 2026, at 9:30 a.m. ET, in Week 4 of the 2026 NFL season.
Venue: Tottenham Hotspur Stadium in London. Washington is the designated home team.
Broadcast: NFL Network.
Starting quarterback update: Marcus Mariota is set for his second Washington start of the season. Jayden Daniels is out with a left-elbow injury.
SportsJaw spread odds: Indianapolis Colts -4.5 (-110); Washington Commanders +4.5 (-110).