Denver Broncos vs Arizona Cardinals prediction, odds and best bet for Week 7
The Denver Broncos will beat the Arizona Cardinals, with a projected score of Broncos 24, Cardinals 20. Denver’s takeaway production is the strongest reason to favor the visitors, while Arizona’s recent defensive improvement makes a comfortable win less certain. Neither Denver -4 (-112) nor the total of 43.5 offers a strong enough edge for an actionable wager. The official recommendation is Pass.
Denver Broncos vs Arizona Cardinals prediction and best bet
Denver gets the pick because its defensive disruption offers the most persuasive route to victory. The Broncos have 10 takeaways, tied for third-most in the NFL, and Arizona’s season-long scoring defense gives Denver another opening. Those factors favor the visitors without making a decisive road win the only reasonable outcome.
The best betting decision is Pass. Arizona just held the Rams to 16 points, and Denver’s offense is still seeking consistency. A Broncos 24, Cardinals 20 forecast lands directly on the four-point spread and close to the total, leaving neither market with a convincing cushion.
Odds, game time and how to watch
Game time: Sunday, October 25, 2026, in Week 7 of the NFL season. Kickoff is 1:05 p.m. MST in Arizona, corresponding to Denver’s listed 2:05 p.m. MT.
Venue: State Farm Stadium.
Broadcast: CBS, with Kevin Harlan, Trent Green and Melanie Collins listed on the broadcast crew.
Records and streaks: Denver is 4-2 and seeking a third consecutive victory. Arizona is 2-4 after its October 18 win over the Rams.
SportsJaw odds: Denver Broncos -4.5 (-114); Arizona Cardinals +4.5 (-106). Moneyline: Denver Broncos -225; Arizona Cardinals +191. Total: Over 44 (-110); Under 44 (-110).