Detroit Lions vs Arizona Cardinals Prediction, Odds and Best Bet for October 11, 2026
The Detroit Lions will beat the Arizona Cardinals, Lions 30, Cardinals 24, in our Week 5 forecast. Detroit’s strongest advantage is its offensive production, with Jared Goff coming off a 412-yard passing game and Jahmyr Gibbs leading the NFL in touches. Neither Detroit -5.5 (-110) nor the total of 54.5 (-110) offers enough projected separation for an actionable wager. The official recommendation is Pass.
Detroit Lions vs Arizona Cardinals prediction and best bet
Detroit gets the pick because its recent passing production and Gibbs’ substantial role offer the stronger offensive case. Arizona enters with three consecutive losses and a quarterback coming off three interceptions. Those factors favor the Lions, although Detroit’s own injury list keeps this from being a high-confidence forecast.
The best betting decision is Pass. Our Lions 30, Cardinals 24 projection puts Detroit just half a point beyond the supplied spread and the combined score half a point below the total. Those narrow differences are too fragile to justify either wager at -110. Picking Detroit to win requires less conviction than backing it to cover 5.5 points.
Odds, game time and how to watch
Game time: Sunday, October 11, 2026, at 4:25 p.m. ET and 1:25 p.m. MST. This is a Week 5 matchup in the 2026 NFL season.
Venue: State Farm Stadium in Glendale, Arizona.
Broadcast: FOX, with Kevin Kugler, Daryl Johnston and Allison Williams assigned to the game.
Records and schedule: Detroit is 2-2 and making its third road trip of the season before its Week 6 bye. Arizona is 1-3, with three straight losses following an opening win over the Los Angeles Chargers.