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  2. NCAAF Picks
  3. Colorado Buffaloes vs Northwestern Wildcats
Sat 7:30 PM ET
Colorado Buffaloes logo
Colorado
Buffaloes7
2-0
versus
Northwestern Wildcats logo
Northwestern
Wildcats41
1-0
Final
Team1234T
Colorado Buffaloes00707
Northwestern Wildcats71414641
NCAAF · Colorado Buffaloes at Northwestern Wildcats

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Colorado at Northwestern: Early scoring leaves the betting edge unsettled

Game time: September 19, 2026 at 7:30 PM ET

Venue: Northwestern Medicine Field at Martin Stadium — Evanston, IL

Article updated Sep 18, 8:37 AM EDT

By SportsJaw Editorial Team

Colorado's latest offensive performance and Northwestern's extra preparation offer competing reasons for interest, without establishing a clear wager.

Production meets extra preparation

Colorado visits Northwestern in Evanston on Saturday, September 19, in a 2026 college football matchup confirmed by both schools. The Buffaloes enter 2-0, while the Wildcats are 1-0 following a bye.

Colorado beat Weber State 52-21 behind Julian Lewis, who completed 17 of 23 passes for 366 yards and four touchdowns and added a rushing touchdown. The Buffaloes finished with 578 total yards and scored 42 points before halftime.

That production included Micah Welch's 106 rushing yards on 11 carries. Joseph Williams contributed 123 receiving yards and two touchdowns, while DeAndre Moore Jr. added 107 receiving yards and a touchdown. Those performances establish what Colorado accomplished against Weber State; they do not establish how effectively Northwestern can defend those threats.

Northwestern won its opener 34-18 over South Dakota State without trailing, then had an additional preparation week. That is relevant context, but the available results do not establish a defensive advantage or justify a specific winning margin.

The prices and the decision

SportsJaw lists Colorado +3.5 (-111) and Northwestern -3.5 (-103), with moneylines of +145 and -170, respectively. Colorado's scoring offers a reason to consider the underdog, but the evidence is too limited to conclude that either spread price offers value.

The September 16 betting snapshot showed Colorado receiving 62% of spread tickets and 84% of spread money. Those figures describe that source's betting activity, not Colorado's probability of covering, and provide no independent reason to back or oppose the Buffaloes.

21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

SportsJaw's total is 48, with over 48 (-106) and under 48 (-114). The teams' cited scoring performances make the over worth examining, but insufficient defensive and possession-level evidence leaves that case incomplete. The selection is Pass, with no projected winner or score.

SportsJaw betting lean

Pass.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Pass

Pick on the Total

Published pick: Pass

Sources

  • Northwestern Wildcats Official Athletics Website'Cats Host Colorado in Lakefront Finale
  • University of Colorado AthleticsThe Road Ahead—Northwestern: Presented by Progressive
  • Fade the Public AnalyticsColorado vs. Northwestern Betting Splits — September 19, 2026
#ColoradoBuffaloes#NorthwesternWildcats

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Written by

SportsJaw Editorial Team

SportsJaw's editorial organization researches matchup data, current odds, injuries and reporting, then validates each published preview against its listed sources and displayed markets.

About our editorial process

SportsJaw Buffaloes vs Wildcats game preview analysis and predictions incorporate current odds, injury reports, team statistics and market data. Information is updated regularly, but lines and player availability can change. Please confirm current information before wagering. View history of past Buffaloes vs Wildcats matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Colorado Buffaloes+139 → +155Moved
  • Moneyline · Northwestern Wildcats-217 → -175Moved
  • Spread · Colorado Buffaloes+5.5 (-110) → +3.5 (-115)Moved
  • Spread · Northwestern Wildcats-5.5 (-110) → -3.5 (-105)Moved
  • Total · Over45.5 (-110) → 48 (-110)Moved
  • Total · Under45.5 (-110) → 48 (-110)Moved

ATS and O/U trends

Colorado Buffaloes
2-0 matchup record · 4-6-0 ATS · 4-6-0 O/U
Last 10 completed games on file
Northwestern Wildcats
1-0 matchup record · 6-2-2 ATS · 6-4-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2026-09-14T10:54:48.502Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Northwestern Wildcats defeated Colorado Buffaloes 41-7

Northwestern Wildcats defeated Colorado Buffaloes 41-7 on September 19, 2026, a 34-point decision in the series. Northwestern Wildcats' strongest period was the 2nd quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Colorado Buffaloes +3.5 (-115) spread, Northwestern Wildcats covered, while the 48 total pushed.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable
  • SpreadPassPass
  • TotalPassPass

Tipster picks

  • KrockpicksSpread · Northwestern Wildcats +4.5 (-110)Win
  • TphamSpread · Colorado Buffaloes +4.5 (-115)Loss
  • MikeVargasSpread · Northwestern Wildcats -3.5 (-115)Win
  • RainmanTotal · Over 48 (-110)Push
  • ThehitmanSpread · Northwestern Wildcats -3.5 (-105)Win
  • Amp2224Spread · Colorado Buffaloes +3.5 (-110)Loss