| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Louisville CardinalsLOUISV | 28 | -385 W | -10 (-110) W | O 52.5 (-110) L U 52.5 (-110) W |
| Virginia Tech HokiesVTECH | 16 | +306 L | +10 (-110) L |
Louisville Cardinals defeated Virginia Tech Hokies 28-16
Louisville Cardinals defeated Virginia Tech Hokies 28-16 on November 1, 2025, a 12-point decision in the series. Louisville Cardinals' strongest period was the 3rd quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Louisville Cardinals -10 (-110) spread, Louisville Cardinals covered, while the 44 combined points finished under the recorded total of 52.5.
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