Kentucky Wildcats vs Missouri Tigers Prediction, Odds and Best Bet for Nov. 21, 2026
Missouri is projected to beat Kentucky 24-20, with Austin Simmons’ recent touchdown production offering the strongest matchup reason against a Wildcats offense coming off a 242-yard performance. Kentucky’s better overall and SEC records make this a low-confidence forecast. Neither the supplied Missouri -6.5 (-9,900) spread nor the 50.5 total offers a strong enough case for a wager; SportsJaw’s official recommendation is Pass.
Kentucky Wildcats vs Missouri Tigers prediction and best bet
Missouri is the pick to win a close game in Columbia. Simmons threw three touchdown passes at Georgia, while Kentucky scored 14 points against Florida. Those contrasting offensive performances give the Tigers a slight editorial edge, although results against different opponents are an imperfect comparison.
The best betting decision is Pass. A four-point Missouri victory would favor Kentucky against the supplied 6.5-point spread, but Kentucky’s -9,900 price demands far more certainty than this matchup warrants. The projected 44 points lean below 50.5, yet the scoring evidence is too mixed for an official Under wager.
Odds, game time and how to watch
Date and location: Nov. 21, 2026, in Columbia, Missouri. Kentucky visits Missouri in this 2026 college football matchup.
Broadcast: SEC Network, according to Kentucky’s Nov. 14 postgame report.
SportsJaw odds: Kentucky Wildcats +5.5 (-100); Missouri Tigers -5.5 (-150). Moneyline: Kentucky Wildcats +160; Missouri Tigers -203. Total: Over 48.5 (-110); Under 48.5 (-110).
Records and streaks: Kentucky is 7-3 overall and 5-3 in the SEC. Missouri is 6-4 overall and 3-4 in conference play, with a two-game losing streak.