Colorado Buffaloes vs Oklahoma St. Cowboys prediction: Cowboys favored, spread a Pass
Oklahoma State will beat Colorado, 35-20, behind Drew Mestemaker and an offense averaging 517.7 yards per game. The Cowboys' passing production and protection give them the strongest matchup advantage, while Colorado's disruptive defense makes a comfortable margin less certain. Neither Oklahoma State -13.5 (-110) nor the total of 56 offers a compelling betting edge. The official recommendation is Pass.
Colorado Buffaloes vs Oklahoma St. Cowboys prediction and best bet
Oklahoma State is the pick to win because its offensive production has been both substantial and sustained. The Cowboys average 37.2 points and have exceeded 30 in five consecutive games. Colorado averages 19.5 points, making its task more demanding if this becomes a game of trading touchdowns.
Winning and covering require different judgments. Oklahoma State -13.5 (-110) needs a victory by at least 14 points, and our forecast clears that threshold by just one point. Colorado's defensive disruption, its competitive showing against Utah and Oklahoma State's defensive problems at Houston make that cushion too small for a spread wager. Best bet: Pass, with medium confidence in the game forecast.
Odds, game time and how to watch
Kickoff: Saturday, October 24, 2026, at 5:05 p.m. MT, according to Colorado's official preview.
Venue: Boone Pickens Stadium, Stillwater, Oklahoma. Oklahoma State's 105th Homecoming game is sold out.
Broadcast: FS1.
Records: Colorado Buffaloes 2-4; Oklahoma St. Cowboys 3-2.
SportsJaw odds: Colorado Buffaloes +13 (-110); Oklahoma St. Cowboys -13 (-110). Moneyline: Colorado Buffaloes +400; Oklahoma St. Cowboys -525. Total: Over 55.5 (-108); Under 55.5 (-112).