Iowa St. Cyclones vs Arizona Wildcats prediction: Arizona -10
Arizona will beat Iowa State, Arizona 31, Iowa State 17, with its productive passing attack providing the strongest matchup advantage. The Wildcats average 306.7 passing yards per game and bring a defense with 19 sacks into this matchup. Arizona -10 (-110) offers an actionable spread wager, although Aiden Flora’s rushing efficiency makes the cover less certain than the outright win.
Iowa St. Cyclones vs Arizona Wildcats prediction and best bet
Arizona -10 (-110) is the best bet. The Wildcats combine a 55.6% third-down conversion rate with 35.7 points per game, giving them a credible route to building a lead even if Iowa State establishes its running game. Sustaining possessions matters here: the Cyclones would benefit from keeping Noah Fifita off the field.
Iowa State’s receiver losses and Arizona’s pass rush strengthen the case for laying 10 points. The risk is that Flora creates enough productive rushing possessions to keep the margin close. Arizona has the stronger overall scoring case, but this is a medium-confidence selection. The forecast is Arizona 31, Iowa State 17; the total of 51 is a separate pass.
Odds, game time and how to watch
Game: Saturday, October 24, 2026. Big 12 college football. Kickoff: 4:30 p.m. MST, 6:30 p.m. CT.
Venue: Casino Del Sol Stadium, Tucson, Arizona. Television: ESPN2.
Records: Iowa St. Cyclones 3-3; Arizona Wildcats 5-1.
SportsJaw spreads: Iowa State +10 (-110); Arizona -10 (-110). Moneylines: Iowa State +260; Arizona -310.
SportsJaw total: Over 51 (-110) or Under 51 (-110).