Missouri Tigers vs Mississippi Rebels Predictions October 17, 2026
Mississippi will beat Missouri 31-27 in our forecast, with Trinidad Chambliss' passing and rushing production giving the Rebels the edge in Oxford. Missouri's productive ground game and recent defensive performance make the Tigers competitive enough to back against the spread. Missouri +6.5 (-110) is the strongest wager at the supplied price, though confidence is low; the total of 57.5 is a pass.
Missouri Tigers vs Mississippi Rebels prediction and best bet
The pick is Mississippi to win, with Missouri +6.5 (-110) the best bet. Chambliss gives the Rebels a credible route to victory against a Missouri defense coming off an excellent performance. His threat as both a passer and runner is the strongest reason to favor the home team.
The spread asks a different question: can Mississippi win by at least seven? Missouri's combination of Jamal Roberts on the ground and a defense that just kept Texas A&M out of the end zone makes a competitive finish a reasonable forecast. A narrow Rebels victory fits both sides of that assessment.
This is a modest edge, not a commanding one. Mississippi's four takeaways against Vanderbilt show the danger to the underdog if turnovers overwhelm Missouri's ability to sustain drives.
Odds, game time and how to watch
Game time: Saturday, Oct. 17, 2026, at 2:30 p.m. CT. Missouri visits Mississippi in this 2026 college football matchup.
Venue: Vaught-Hemingway Stadium in Oxford, Mississippi.
Broadcast: The Oct. 5 Ole Miss Athletics announcement named ABC, ESPN or SEC Network as possibilities, with the final assignment scheduled for the following week.