Ohio St. Buckeyes vs Indiana Hoosiers Betting Picks & Predictions
Ohio State will beat Indiana 27-24 in our forecast, with Julian Sayin’s passing efficiency and Jeremiah Smith’s receiving production supplying the strongest reason to favor the Buckeyes. Indiana’s disruptive defense makes that a narrow, low-confidence choice. Neither Ohio State -3 (-108) nor the 50.5 total offers enough projected value for an actionable wager, so the official SportsJaw betting lean is Pass.
Ohio St. Buckeyes vs Indiana Hoosiers prediction and best bet
Ohio State gets the nod because its passing attack offers a compelling route through a difficult defensive matchup. Sayin’s efficiency and Smith’s scoring production suggest the Buckeyes can generate enough offense even if Indiana makes sustained rushing success difficult. The forecast is Ohio State 27, Indiana 24.
The best betting decision is Pass. Indiana brings both defensive disruption and a productive quarterback, making a decisive Ohio State advantage difficult to identify. A three-point projected margin lands exactly on the spread, while 51 projected points sit only half a point above the total. Neither difference warrants paying the supplied price.
Odds, game time and how to watch
Game: No. 4 Ohio St. Buckeyes at No. 5 Indiana Hoosiers, a 2026 college football matchup.
Kickoff: Saturday, October 17, 2026, noon ET.
Broadcast: FOX. Streaming: FOX One.
Projected starting quarterbacks: Julian Sayin for Ohio State; Josh Hoover for Indiana.
SportsJaw odds: Ohio St. Buckeyes -2.5 (-115); Indiana Hoosiers +2.5 (-105). Moneyline: Ohio St. Buckeyes -145; Indiana Hoosiers +125. Total: Over 49.5 (-106); Under 49.5 (-110).