| Score | Moneyline | Spread | Game total | |
|---|---|---|---|---|
| Louisiana-Monroe WarhawksUL.MON | 21 | +415 L | +13.5 (-110) L | O 49.25 (-110) W U 49.25 (-110) L |
| Southern Miss. Golden EaglesS.MISS | 49 | -550 W | -13.5 (-110) W |
Southern Miss. Golden Eagles defeated Louisiana-Monroe Warhawks 49-21
Southern Miss. Golden Eagles defeated Louisiana-Monroe Warhawks 49-21 on October 25, 2025, a 28-point decision in the series. Southern Miss. Golden Eagles' strongest period was the 3rd quarter, when it outscored its opponent 14-0. Against SportsJaw's recorded Louisiana-Monroe Warhawks +13.5 (-110) spread, Southern Miss. Golden Eagles covered, while the 70 combined points finished over the recorded total of 49.25.
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