SE Missouri St. Indians vs South Carolina Gamecocks prediction, odds and projected score
South Carolina will beat SE Missouri St. 81-65 in our forecast, with Juan Fernandez’s efficient scoring and the Gamecocks’ balanced opener providing the strongest matchup reason. SEMO’s productive start makes the 17.5-point spread less appealing than the outright prediction. Neither South Carolina -17.5 (-110), SEMO +17.5 (-110), nor the supplied 145.5 total offers a convincing betting advantage. The official wager is Pass.
SE Missouri St. Indians vs South Carolina Gamecocks prediction and best bet
South Carolina is the pick to win, but the best betting decision is Pass. Its 81-55 opening victory over Stetson featured 50.8% shooting and five double-figure scorers, according to CBS Sports. That gives the Gamecocks a credible offensive foundation for this matchup without requiring Fernandez to supply all their points.
SEMO brings its own balanced scoring after two wins. Asking South Carolina to win by at least 18 points is a substantially different proposition from asking it to win. Our forecast puts the margin at 16, a small cushion for the underdog against the spread. With such limited early-season results, that difference is too fragile to make SEMO an official wager.
Odds, game time and how to watch
Game time: Sunday, November 8, 2026, at 1 p.m. ET. This is a 2026-27 men’s college basketball matchup.
Venue: Colonial Life Arena, Columbia, South Carolina.
Broadcast: SECN+.
Records: SE Missouri St. Indians 1-0; South Carolina Gamecocks 1-0.
SportsJaw odds: SE Missouri St. Indians +17.5 (-110); South Carolina Gamecocks -17.5 (-110). Moneyline: SE Missouri St. Indians +1,156; South Carolina Gamecocks -2,500. Total: Over 145 (-110); Under 145 (-110).



