Southern Miss. Golden Eagles vs Iowa St. Cyclones prediction, odds and best bet for Nov. 6
Iowa State will beat Southern Miss, with a projected score of Iowa State 84, Southern Miss 62. Four double-figure scorers against Memphis give the Cyclones several offensive options as they return to Hilton Coliseum. The supplied prices offer no compelling wager: our spread and total recommendations are both Pass, despite a forecast that favors Southern Miss covering and a finish below 150.5.
Southern Miss. Golden Eagles vs Iowa St. Cyclones prediction and best bet
Iowa State is the straight-up selection, but the official betting call is Pass. The Cyclones scored 76 points against Memphis with contributions from four double-figure scorers, according to Southern Miss Athletics’ matchup preview. That distribution is the strongest basketball reason to expect enough offense to win at home.
The distinction comes at the price. Iowa State -31.5 (-105) requires a much larger victory than our projected 22-point margin. Southern Miss +31.5 (-115) is more appealing directionally, while the projected 146 points lean under. Neither forecast difference alone is enough to justify a wager with only one game of current-season results for each team.
Odds, game time and how to watch
Game: Southern Miss. Golden Eagles at Iowa St. Cyclones, 2026-27 men’s college basketball.
Tipoff: Friday, November 6, 2026, at 7 p.m. CT. Southern Miss Athletics confirms the time; Covers lists the equivalent 8 p.m. ET.
Venue: Hilton Coliseum, Ames, Iowa. Broadcast: ESPN+.
Records: Southern Miss. Golden Eagles 0-0; Iowa St. Cyclones 0-1.
SportsJaw odds: Southern Miss. Golden Eagles +30.5 (-106); Iowa St. Cyclones -30.5 (-110). Moneyline: Southern Miss. Golden Eagles +3,300; Iowa St. Cyclones -10,000. Total: Over 150.5 (-110); Under 150.5 (-110).