South Florida Bulls vs DePaul Blue Demons Prediction, Odds and Best Bet
DePaul is our pick to beat South Florida 78-74, with Magoon Gwath’s productive debut and contributions from several teammates giving the home team a slight advantage. The Bulls’ balanced scoring in their opener is the strongest counterargument. Neither DePaul -6.5 (-110) nor the total of 150.5 (-110) offers a convincing wager, so the official SportsJaw betting recommendation is Pass.
South Florida Bulls vs DePaul Blue Demons prediction and best bet
DePaul gets the nod in this Nov. 5 matchup, but the forecast carries low confidence. The Blue Demons showed several ways to generate offense in their opening victory, from bench scoring to perimeter shooting and passing. Gwath’s scoring and defensive contributions make him the most compelling individual reason to favor DePaul at home.
South Florida’s opening performance makes a comfortable DePaul win harder to project. The Bulls produced the higher scoring total and had five players reach double figures. Our four-point projected margin favors South Florida against the spread on paper, but that modest cushion is too fragile to turn into a bet. The best betting decision is Pass.
Odds, game time and how to watch
Game time: Thursday, Nov. 5, 2026, at 8:30 p.m. ET, or 7:30 p.m. CT. This is a 2026-27 men's college basketball matchup.
Venue: Wintrust Arena in Chicago, Illinois.
Broadcast: truTV.
Records: South Florida Bulls 1-0; DePaul Blue Demons 1-0.
SportsJaw odds: South Florida Bulls +6.5 (-110); DePaul Blue Demons -6.5 (-110). Moneyline: South Florida Bulls +240; DePaul Blue Demons -290. Total: Over 150.5 (-110); Under 150.5 (-110).



