Southern U. Jaguars vs Iowa St. Cyclones prediction, odds and best bet for Nov. 10
Iowa State is our projected winner over Southern, 89-59, on Tuesday, Nov. 10. Tre Singleton’s 28-point performance in the Cyclones’ latest victory is the strongest current reason to favor Iowa State against the 0-3 Jaguars. The supplied Southern +35.5 (-110) offers a substantial cushion, but neither that spread nor the 147.5 total earns an actionable wager. Our official recommendation is Pass.
Southern U. Jaguars vs Iowa St. Cyclones prediction and best bet
Iowa State is the pick to win this 2026-27 men’s college basketball matchup, with a projected score of Iowa State 89, Southern 59. The Cyclones enter 1-1 after beating Southern Miss 83-57, according to the Associated Press. Southern enters 0-3.
The best betting decision is Pass. A convincing Iowa State victory and a Cyclones spread cover are different propositions at -35.5 (-110). Our forecast favors Southern against that number, but the evidence behind the precise margin is too thin to make it the official wager.
Other analysts agree on the winner without offering identical betting conclusions. Dimers projects Iowa State by 28 points, The Breakdown projects a 34.3-point margin, and Pick Dawgz writer Andrew Jett selects Iowa State without a specific spread recommendation. That agreement strengthens the winner lean, but it is not three independent demonstrations of betting value.
Odds, game time and how to watch
Time: Tuesday, Nov. 10, 2026, at 8 p.m. EST, according to the Associated Press. Covers also identifies this matchup for Nov. 10 at 8 p.m. ET.
Location: Ames, Iowa.
Records: Southern U. Jaguars 0-3; Iowa St. Cyclones 1-1.