Cleveland Cavaliers vs Philadelphia 76ers Predictions October 22, 2026
The Cleveland Cavaliers are projected to beat the Philadelphia 76ers 118-116 on Thursday, October 22. Cleveland’s four-game sweep last season supplies the strongest matchup reason, while Philadelphia’s season-opening victory makes this a low-confidence call. Neither Cleveland +2.5 (-107) nor the total of 235.5 (-110) offers a strong enough edge for an official wager. The betting recommendation is Pass.
Cleveland Cavaliers vs Philadelphia 76ers prediction and best bet
Cleveland gets the narrow forecast advantage because it won all four meetings with Philadelphia in 2025-26. That history is relevant, but carrying it into a new season requires restraint. Philadelphia has already delivered a road victory, and its current production is the strongest reason this prediction could miss.
The best betting decision is Pass. Cleveland +2.5 (-107) offers a cushion, but a projected Cavaliers victory is not enough by itself to prove the spread is mispriced. The forecast favors Cleveland slightly; the wager assessment leaves both markets alone.
Odds, game time and how to watch
Game: Cleveland Cavaliers at Philadelphia 76ers, NBA, 2026-27 season. Thursday, October 22, 2026, at 7:00 p.m. ET.
Venue: Xfinity Mobile Arena, Philadelphia, Pennsylvania. Broadcast: ESPN.
SportsJaw odds: Cleveland Cavaliers +3 (-112); Philadelphia 76ers -3 (-108). Moneyline: Cleveland Cavaliers +127; Philadelphia 76ers -147. Total: Over 235.5 (-110); Under 235.5 (-110).
Record: Philadelphia is 1-0 following its October 20 win at New York.
Projected starters: Cleveland lists James Harden, Donovan Mitchell, Evan Mobley, Peyton Watson and Jarrett Allen. Philadelphia lists Tyrese Maxey, VJ Edgecombe, Jaylen Brown, LeBron James and Joel Embiid. These are projections, not confirmed starting lineups.



