St. Louis Cardinals vs Milwaukee Brewers Predictions Today: Andre Pallante vs Jacob Misiorowski
The Milwaukee Brewers will beat the St. Louis Cardinals, with a projected score of Brewers 5, Cardinals 2. Jacob Misiorowski's 1.86 ERA and strong results against St. Louis give Milwaukee its strongest advantage. Brewers -1.5 (+100) is an actionable run-line wager at medium confidence, although Milwaukee's recent bullpen workload presents a risk. The total of 7 is a pass.
St. Louis Cardinals vs Milwaukee Brewers prediction and best bet
Milwaukee -1.5 (+100) is the best bet for this September 27 matchup. Misiorowski brings the stronger season performance and has held St. Louis to four runs across two seven-inning starts in 2026. Milwaukee also averages 5.13 runs per game against the Cardinals' 4.45, giving the Brewers a stronger offensive foundation for a multiple-run victory.
Andre Pallante makes this more competitive than the moneyline alone might suggest. He owns a 3.61 ERA and allowed one run in six innings in his latest dated outing. Still, Milwaukee's success against him and Misiorowski's strikeout advantage favor the Brewers. The run-line selection carries medium confidence, with bullpen workload the biggest concern.
Odds, game time and how to watch
First pitch: Sunday, September 27, 2026, at 3:10 p.m. EDT.
Venue: American Family Field.
Broadcast: Brewers.TV and Cardinals.TV.
Records: Cardinals 77-84, including 39-41 away; Brewers 102-59, including 54-26 at home.
Probable starters: Right-handers Andre Pallante for St. Louis and Jacob Misiorowski for Milwaukee.
SportsJaw moneylines: Cardinals +208; Brewers -235. Run lines: Cardinals +1.5 (-120); Brewers -1.5 (+100). Total: Over 7 (+100); Under 7 (-120).