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  1. Home
  2. MLB Picks
  3. Cleveland Guardians vs St. Louis Cardinals
Sun 2:15 PM ET
Cleveland Guardians logo
Cleveland
Guardians1
G. Williams RHP
versus
St. Louis Cardinals logo
St. Louis
Cardinals2
A. Pallante RHP
Final
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St. Louis Cardinals00000

Cleveland Guardians vs St. Louis Cardinals Betting Picks & Predictions

Game time: September 22, 2024 at 2:15 PM ET

Venue: Busch Stadium — St. Louis, Missouri

Article updated Sep 22, 6:01 PM EDT

Published by SportsJaw Editorial Team

In the final game of the interleague series, the Cleveland Guardians are looking to secure a series win over the St. Louis Cardinals on the road. After a 5-1 victory in the

Game outlook

In the final game of the interleague series, the Cleveland Guardians are looking to secure a series win over the St. Louis Cardinals on the road. After a 5-1 victory in the opening game, Cleveland is one step closer to clinching the AL Central crown. The Cardinals, on the other hand, are hoping to earn a win on getaway day. Gavin Williams (ERA: 5.12) is set to start for the Guardians, while Andre Pallante (ERA: 3.87) will take the mound for the Cardinals. St. Louis is the betting favorite, with the current line favoring them at -125. Stay tuned for the outcome of the middle game at Busch Stadium on Saturday night.

Betting Odds

Moneyline: Guardians +112 | Cardinals -125

Spread: Guardians +1.5 (-190) | Cardinals -1.5 (+165)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that St. Louis will win straight-up is 56%.

Cleveland Guardians

Cleveland continued their winning streak by defeating the Cardinals in the opening game of the series on Friday night. They now hold a 7.5-game advantage on the Royals in the AL Central. Jose Ramirez led the offense with three hits, including a home run, in the victory. Pitcher Ben Lively earned the win, while Gavin Williams will take the mound in the next game. Williams has a 3-10 record this season and will be making his first career start against the Cardinals. Cleveland is ranked 15th in offense, 3rd in defense, and holds a 90-66 record for the season.

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MLB · Cleveland Guardians at St. Louis Cardinals

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St. Louis Cardinals Analysis

The St. Louis Cardinals dropped their second straight game in the opening contest of a series, bringing their season record to 77-77 and placing them third in the NL Central, 11 games behind the Brewers. They are trailing the Mets by eight games for the final wild-card spot with eight games remaining. In their last game, St. Louis picked up seven hits with Thomas Saggese and Lars Nootbaar each recording a pair. Kyle Gibson took the loss on the mound, allowing four runs on six hits over six innings. Andre Pallante will be starting the next game for the Cardinals with a record of 7-8 and a 3.87 ERA for the season. In their last three matchups, Cleveland went 1-2 against St. Louis. The Cardinals are ranked #25 for offense, scoring an average of 4.07 runs per game, and are ranked #19 for defense, giving up an average of 4.47 runs per game.

Guardians Overcome Pitching Flaws to Secure Postseason Spot; Cardinals Focus on Developing Young Talent

Despite inconsistent starting pitching, the Guardians are successfully moving towards the postseason. Williams exemplifies this, struggling individually but benefiting from a strong lineup and reliable bullpen. On the other hand, the Cardinals are unlikely to make the playoffs and are giving younger players playing time. Pallante has shown promise in transitioning from the bullpen, but the overall lack of playoff contention diminishes the team's motivation. As the Guardians strive to sustain their momentum towards the playoffs, their focus remains on solidifying their position in the postseason race.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#ClevelandGuardians#StLouisCardinals

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Guardians vs Cardinals archived game preview contains historical odds and availability that may no longer be current. View history of past Guardians vs Cardinals matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Cleveland Guardians-107 → +115Moved
  • Moneyline · St. Louis Cardinals-109 → -125Moved
  • Spread · Cleveland Guardians-1.5 (+155) → +1.5 (-190)Moved
  • Spread · St. Louis Cardinals+1.5 (-190) → -1.5 (+165)Moved
  • Total · Over7.5 (-110) → 7.5 (-110)Unchanged
  • Total · Under7.5 (-110) → 7.5 (-110)Unchanged

ATS and O/U trends

Cleveland Guardians
85-77 matchup record · 5-5-0 ATS · 2-7-1 O/U
Last 10 completed games on file
St. Louis Cardinals
77-85 matchup record · 7-3-0 ATS · 3-7-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2024-09-22T22:01:04.623Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2024-09-21Cleveland Guardians 5 · St. Louis Cardinals 6
  • 2024-09-20Cleveland Guardians 5 · St. Louis Cardinals 1
Final result

Matchup pick recap

St. Louis Cardinals defeated Cleveland Guardians 2-1

St. Louis Cardinals defeated Cleveland Guardians 2-1 on September 22, 2024, a 1-run decision in the series. St. Louis Cardinals' strongest period was the 7th inning, when it outscored its opponent 1-0. Against SportsJaw's recorded Cleveland Guardians +1.5 (-190) spread, Cleveland Guardians covered, while the 3 combined runs finished under the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.