SportsJaw
LeaderboardToday's GamesBest BetsLive OddsMake Picks
Login / Sign In
Today's GamesLatest PredictionsToday’s Best BetsLive OddsTeam PredictionsHead-to-Head MatchupsSJ CoinsAbout SportsJawContact UsLogin / Sign In
HomeMatchupsMake PicksLeaders
SportsJaw

The social platform for sports bettors.

Explore SportsJaw

  • Today’s Picks
  • Predictions
  • Best Bets
  • Leaderboard
  • Make Picks
  • Live Odds
  • Consensus Picks
  • Team Predictions
  • Head-to-Head
  • Game Briefing

Picks by Sport

  • NFL Picks
  • NCAAF Picks
  • NBA Picks
  • NCAAB Picks
  • MLB Picks
  • NHL Picks

About SportsJaw

  • How It Works
  • SJ Coins
  • Terms
  • Privacy
  • Contact Us

21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

© 2026 SportsJaw. For entertainment purposes only. SportsJaw does not accept or place wagers.

  1. Home
  2. MLB Picks
  3. Chicago White Sox vs San Diego Padres
Sun 4:10 PM ET
Chicago White Sox logo
Chicago
White Sox2
S. Burke RHP
versus
San Diego Padres logo
San Diego
Padres4
Y. Darvish RHP
Final
Team123456789T
Chicago White Sox0010010002
San Diego Padres00100003

Chicago White Sox vs San Diego Padres Betting Picks & Predictions

Game time: September 22, 2024 at 4:10 PM ET

Venue: Petco Park — San Diego, California

Article updated Sep 21, 10:35 PM EDT

Published by SportsJaw Editorial Team

The Chicago White Sox are set to face off against the San Diego Padres at Petco Park for game three of their series. The White Sox, with a record of 84-78, are currently

Game outlook

The Chicago White Sox are set to face off against the San Diego Padres at Petco Park for game three of their series. The White Sox, with a record of 84-78, are currently last in the American League Central, while the Padres, with a record of 91-71, are second in the National League West. The Padres have a perfect 3-0 record against the White Sox this season. The first pitch is scheduled for 4:10 p.m. EST, with Sean Burke (ERA: 2.25) starting for the White Sox and Yu Darvish (ERA: 3.21) starting for the Padres. San Diego is the heavy favorite according to the odds, with the current line at San Diego -320. Our MLB Predictions have a strong track record when it comes to baseball picks.

Betting Odds

Moneyline: White Sox +275 | Padres -320

Spread: White Sox +1.5 (+125) | Padres -1.5 (-142)

Total: Over/Under 8 (-110)

Based on the moneyline, the implied probability that San Diego will win straight-up is 76%.

Chicago White Sox

The Chicago White Sox suffered their fourth consecutive loss yesterday against the San Diego Padres with a final score of 6-2, bringing their overall record on their road trip to 1-4. The team has struggled in all aspects this season, with an ERA of 4.77 and a batting average of .221, both ranking among the worst in the league. Even facing a middling pitcher like Martín Pérez, the White Sox were only able to muster two hits and one run. As the season winds down, the team seems to be focusing on giving younger players more experience. Right-handed pitcher Sean Burke, with a record of 1-0 and an ERA of 2.25, will be starting on Sunday. Overall, the White Sox are ranked last in offense, 28th in defense, and have a record of 84-78 this season.

—
4
MLB · Chicago White Sox at San Diego Padres

Your Picks on White Sox vs Padres

Picks closed
Runline
Moneyline
Total

21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

San Diego Padres Analysis

The San Diego Padres secured a significant 6-2 victory against the Chicago White Sox, marking their third consecutive win and improving their homestand record to 4-1. Currently leading the National League Wild Card with a winning percentage of .574, the Padres are focused on maintaining a favorable playoff position. Their strong offense, ranking highest in hits, has contributed to their success this season, with a recent increase in batting average indicating a heightened level of competitiveness. Right-handed pitcher Yu Darvish, with a record of 6-3 and an ERA of 3.21, started for the Padres, showcasing his impressive performance on the mound. The Padres, ranked 6th in overall power and 8th in offense, are strategically positioning themselves for the postseason, with a keen eye on their competitors in the postseason race.

San Diego Padres Struggle Against White Sox, White Sox Look to Avoid Record Losses

The San Diego Padres have struggled in recent games against the White Sox, with a 3-7 record against the run line in their last 10 matchups. Moreover, the Padres have a season record of 2-6 against the runline specifically in game three of a series when leading 2-0 at home. The White Sox, who have accumulated 119 losses this season, are on course to potentially equal the league record for most losses in a regular season. It is likely that the White Sox will put forth a considerable effort in their remaining games to avoid this dubious achievement and salvage some pride. Given these factors, it seems prudent to consider siding with the White Sox at +1.5.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#ChicagoWhiteSox#SanDiegoPadres

Share this preview

Facebook X Reddit Email
SportsJaw logo
Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw White Sox vs Padres archived game preview contains historical odds and availability that may no longer be current. View history of past White Sox vs Padres matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Chicago White Sox+262 → +280Moved
  • Moneyline · San Diego Padres-300 → -345Moved
  • Spread · Chicago White Sox+1.5 (+112) → +1.5 (+130)Moved
  • Spread · San Diego Padres-1.5 (-130) → -1.5 (-150)Moved
  • Total · Over7.5 (-110) → 8 (-110)Moved
  • Total · Under7.5 (-110) → 8 (-110)Moved

ATS and O/U trends

Chicago White Sox
84-78 matchup record · 5-5-0 ATS · 3-6-1 O/U
Last 10 completed games on file
San Diego Padres
91-71 matchup record · 6-4-0 ATS · 2-6-2 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2024-09-22T02:35:32.046Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2024-09-21Chicago White Sox 2 · San Diego Padres 6
  • 2024-09-20Chicago White Sox 2 · San Diego Padres 3
Final result

Matchup pick recap

San Diego Padres defeated Chicago White Sox 4-2

San Diego Padres defeated Chicago White Sox 4-2 on September 22, 2024, a 2-run decision in the series. San Diego Padres' strongest period was the 8th inning, when it outscored its opponent 3-0. Against SportsJaw's recorded Chicago White Sox +1.5 (+130) spread, San Diego Padres covered, while the 6 combined runs finished under the recorded total of 8.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • JamescashiolaMoneyline · Chicago White Sox +262Loss
  • Lockpicker69Moneyline · Chicago White Sox +262Loss
  • Roderick806Moneyline · San Diego Padres -300Win
  • AliencreationRunline · San Diego Padres -1.5 (-130)Win
  • Hustle$Moneyline · Chicago White Sox +260Loss
  • CoversMoneyline · San Diego Padres -300Win
  • CoolioMoneyline · San Diego Padres -325Win
  • OddssharkMoneyline · San Diego Padres -325Win
  • OddssharkTotal · Over 8 (-110)Loss
  • BooksworstnightmareRunline · San Diego Padres -1.5 (-140)Win
  • BooksworstnightmareTotal · Over 8 (-110)Loss