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  1. Home
  2. MLB Picks
  3. Cleveland Guardians vs St. Louis Cardinals
Sat 7:15 PM ET
Cleveland Guardians logo
Cleveland
Guardians5
M. Boyd LHP
versus
St. Louis Cardinals logo
St. Louis
Cardinals6
M. Mikolas RHP
Final
Team123456789T
Cleveland Guardians0000100405
St. Louis Cardinals000200

Cleveland Guardians vs St. Louis Cardinals Betting Picks & Predictions

Game time: September 21, 2024 at 7:15 PM ET

Venue: Busch Stadium — St. Louis, Missouri

Article updated Sep 20, 10:35 PM EDT

Published by SportsJaw Editorial Team

Despite being underestimated at the start of the season, the Cleveland Guardians have proven to be a consistent and versatile team, boasting a record of 85-77. With their

Game outlook

Despite being underestimated at the start of the season, the Cleveland Guardians have proven to be a consistent and versatile team, boasting a record of 85-77. With their sights set on a deep run in the American League postseason, they face off against the St. Louis Cardinals (77-77) who struggled to maintain their early season success due to a lack of depth in talent. The expected pitching matchup for Saturday's game will be between Matthew Boyd (2.52 ERA) of the Guardians and Miles Mikolas (5.49 ERA) of the Cardinals. Cleveland is the favored team with the opening line at -135, currently sitting at Cleveland -129.

Betting Odds

Moneyline: Guardians -129 | Cardinals +116

Spread: Guardians -1.5 (+130) | Cardinals +1.5 (-149)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that Cleveland will win straight-up is 56%.

Cleveland Guardians

The Cleveland Guardians have been performing exceptionally well this season, winning six of their last seven games and boasting a 42-37 record away from home. Their pitching staff has been a standout, with the fifth best team ERA in baseball, while their offense has exceeded expectations, ranking 14th in total runs scored in the league. The team has multiple strengths that make them a formidable opponent heading into the post-season. Veteran lefty Matthew Boyd has been particularly impressive, with a 6-1 record in seven starts and a 2.52 ERA. In their last game, the Guardians secured a crucial 5-1 victory with Jose Ramirez delivering two RBI and Ben Lively pitching five solid innings. With a power ranking of 10, Cleveland is ranked 14 in offense, #3 in defense, and currently hold a 90-65 record for the season.

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MLB · Cleveland Guardians at St. Louis Cardinals

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St. Louis Cardinals Analysis

The St. Louis Cardinals had a promising start to the season but struggled to maintain their momentum as the year went on. Despite having a solid home record, they currently sit third in the NL Central and are unlikely to compete for a playoff spot. The team's biggest weakness this season has been their lineup, which ranks 24th in the league in runs scored. Although their ERA is decent, it hasn't been enough to secure consistent wins. Looking ahead to the offseason, the Cardinals will need to regroup and make strategic moves to improve. Right-hander Miles Mikolas has had a difficult season, with a disappointing ERA of 5.29. In their last game against the Guardians, the Cardinals fell short despite a strong pitching performance from Kyle Gibson. The Cardinals have a power ranking of 15 and are ranked 24th in offense and 19th in defense, with an overall record of 77-85. Cleveland recently won two out of three matchups against St. Louis.

Guardians Riding Momentum Against Cardinals, Favored for Victory

Historically, the Cardinals have had the upper hand in the matchup against the Guardians. However, recent trends indicate a shift in momentum, with the Guardians holding a 3-1 record in their most recent meetings. Over the past two years, the Guardians have outscored the Cardinals 14-9, reflecting a more competitive dynamic between the teams. Notably, Miles Mikolas has struggled with a 6.54 ERA at home this season, while the Guardians have been strong with a 7-3 record in their last eight home games. Given these factors, it is likely that the AL Central leaders will secure another significant victory in this upcoming matchup.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#ClevelandGuardians#StLouisCardinals

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Guardians vs Cardinals archived game preview contains historical odds and availability that may no longer be current. View history of past Guardians vs Cardinals matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Cleveland Guardians-135 → -123Moved
  • Moneyline · St. Louis Cardinals+120 → +113Moved
  • Spread · Cleveland Guardians-1.5 (+125) → -1.5 (+132)Moved
  • Spread · St. Louis Cardinals+1.5 (-145) → +1.5 (-152)Moved
  • Total · Over8 (-110) → 7.5 (-110)Moved
  • Total · Under8 (-110) → 7.5 (-110)Moved

ATS and O/U trends

Cleveland Guardians
85-77 matchup record · 6-4-0 ATS · 2-7-1 O/U
Last 10 completed games on file
St. Louis Cardinals
77-85 matchup record · 6-4-0 ATS · 2-8-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2024-09-21T02:35:32.447Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2024-09-20Cleveland Guardians 5 · St. Louis Cardinals 1
Final result

Matchup pick recap

St. Louis Cardinals defeated Cleveland Guardians 6-5

St. Louis Cardinals defeated Cleveland Guardians 6-5 on September 21, 2024, a 1-run decision in the series. St. Louis Cardinals' strongest period was the 7th inning, when it outscored its opponent 4-0. Against SportsJaw's recorded Cleveland Guardians -1.5 (+132) spread, St. Louis Cardinals covered, while the 11 combined runs finished over the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

  • MoneymouthMoneyline · Cleveland Guardians -132Loss
  • IrishblueTotal · Over 8 (-110)Win