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  1. Home
  2. MLB Picks
  3. Chicago Cubs vs Cincinnati Reds
Fri 6:40 PM ET
Chicago Cubs logo
Chicago
Cubs4
C. Holmes RHP
versus
Cincinnati Reds logo
Cincinnati
Reds6
C. Burns RHP
Final
Team123456789T
Chicago Cubs0112000004
Cincinnati Reds20100300—6

Cubs vs. Reds: Chicago Moneyline Gets a Cautious Lean

Game time: September 18, 2026 at 6:40 PM ET

Venue: Great American Ball Park — Cincinnati, Ohio

Article updated Sep 18, 10:57 AM EDT

By SportsJaw Editorial Team

The Cubs have the stronger season profile, but uneven results from Clay Holmes and Chase Burns’ previous outing against Chicago keep confidence low.

Chicago’s season numbers support the price

The Chicago Cubs visit the Cincinnati Reds on September 18 in this 2026 MLB matchup, with Clay Holmes and Chase Burns listed as the starters. SportsJaw prices Chicago at -126 on the moneyline and Cincinnati at +113.

Chicago’s clearest advantage comes from its overall production. The Cubs are 85-68, averaging 5.34 runs scored and 4.41 allowed per game. Cincinnati is 71-82, averaging 4.14 scored and 5.14 allowed. Those figures favor Chicago on both sides of the scoring ledger, while the Reds have lost eight of their last 10 games. They support a Cubs lean without establishing a precise probability of winning.

The starters leave room for doubt

Holmes allowed eight earned runs in 4 1/3 innings at Miami on September 6. Against Pittsburgh on September 12, he surrendered three runs, two earned, over 5 2/3 innings, with five hits, four walks and six strikeouts. That improvement matters, but the walks and preceding rough start make a strong pitching-edge claim difficult to defend.

Burns provides meaningful counterevidence. Against the Cubs on August 30, he allowed three runs, two earned, in 5 2/3 innings, striking out seven and walking one. Cincinnati won 7-5. Chicago’s stronger season offense therefore does not guarantee it will control this particular matchup.

Prediction and betting lean

The selection is Chicago Cubs moneyline (-126), with low confidence and a projected 5-4 Cubs win. Chicago’s broader scoring and run-prevention advantages carry the recommendation; the pitching evidence keeps it cautious.

MLB · Chicago Cubs at Cincinnati Reds

Your Picks on Cubs vs Reds

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21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

SportsJaw lists over 8.5 (-120) and under 8.5 (+100). The projected nine runs sit above that threshold, but a narrow score projection alone does not establish value on the over. The moneyline remains the single selection.

SportsJawGame Predictions
Predicted score

Cubs5

Reds4

Projected winner Chicago CubsConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

Pick on the Moneyline

Published pick: Chicago Cubs moneyline (-126)

Sources

  • CoversCubs vs Reds Game Overview, Stats, Injuries, Records - MLB Game on September 18, 2026
  • MLB.comChase Burns against the Cubs | 09/18/2026 | Cincinnati Reds
#ChicagoCubs#CincinnatiReds

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Written by

SportsJaw Editorial Team

SportsJaw's editorial organization researches matchup data, current odds, injuries and reporting, then validates each published preview against its listed sources and displayed markets.

About our editorial process

SportsJaw Cubs vs Reds game preview analysis and predictions incorporate current odds, injury reports, team statistics and market data. Information is updated regularly, but lines and player availability can change. Please confirm current information before wagering. View history of past Cubs vs Reds matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Chicago Cubs-130 → -145Moved
  • Moneyline · Cincinnati Reds+110 → +131Moved
  • Spread · Chicago Cubs-1.5 (+125) → -1.5 (+110)Moved
  • Spread · Cincinnati Reds+1.5 (-145) → +1.5 (-130)Moved
  • Total · Over8.5 (-120) → 8.5 (-113)Moved
  • Total · Under8.5 (+100) → 8.5 (-107)Moved

ATS and O/U trends

Chicago Cubs
72-60 matchup record · 5-5-0 ATS · 6-2-2 O/U
Last 10 completed games on file
Cincinnati Reds
56-73 matchup record · 3-7-0 ATS · 4-5-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2026-09-18T14:57:44.800Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2026-08-30Cincinnati Reds 7 · Chicago Cubs 5
  • 2026-08-29Cincinnati Reds 5 · Chicago Cubs 17
  • 2026-08-28Cincinnati Reds 10 · Chicago Cubs 8
Final result

Matchup pick recap

Cincinnati Reds defeated Chicago Cubs 6-4

Cincinnati Reds defeated Chicago Cubs 6-4 on September 18, 2026, a 2-run decision in the series. Cincinnati Reds' strongest period was the 6th inning, when it outscored its opponent 3-0. Against SportsJaw's recorded Chicago Cubs -1.5 (+110) spread, Cincinnati Reds covered, while the 10 combined runs finished over the recorded total of 8.5.

SportsJaw editorial picks

  • Projected winnerChicago CubsLoss
  • MoneyChicago Cubs moneyline (-126)Loss

Tipster picks

  • Steve512Total · Over 8.5 (+100)Win
  • RcollinsMoneyline · Cincinnati Reds +110Win
  • CodexMoneyline · Chicago Cubs -126Loss