Boston Red Sox vs San Diego Padres Betting Picks & Predictions

Game outlook

The 2025 Major League Baseball season kicks off on Friday, August 8, with the Boston Red Sox facing off against the San Diego Padres at Petco Park in San Diego, California. Last season, the Padres won two out of three games against the Red Sox at Fenway Park. The Padres are currently favored to win with a moneyline of -165 and a total of 8.5 runs. Stay tuned for our Red Sox vs. Padres prediction as we analyze this interleague showdown as part of our MLB picks for Friday's games. The game is set to start at 9:40 PM ET.

Betting Odds

Moneyline: Red Sox +148 | Padres -168

Spread: Red Sox +1.5 (-140) | Padres -1.5 (+120)

Total: Over/Under 8 (-110)

Based on the moneyline, the implied probability that San Diego will win straight-up is 63%.

Boston Red Sox

The Boston Red Sox have been on a successful streak recently, winning four consecutive three-game series against tough opponents. While they suffered a 7-3 loss to the Kansas City Royals, ending a seven-game winning streak, the Red Sox still hold the top wild card spot in the American League. So far in August, the team has scored 32 runs and their bullpen has been performing well. Walker Buehler will be pitching for the Red Sox on Friday night, with a decent record against the San Diego Padres in his career.

San Diego Padres

The San Diego Padres are on a hot streak, coming off a 3-2 win against the Arizona Diamondbacks which secured their third straight series win. They currently hold the second wild card spot in the National League and are only two games behind the NL West-leading Los Angeles Dodgers. In August, the Padres have scored 31 runs in their first six games, with impressive stats for their hitting and bullpen performances. Nick Pivetta will be pitching on Friday night with an impressive record of 11-3 and a 2.73 ERA in 2025. Pivetta last faced the Red Sox in 2018, with only two players from the current Boston team having previous at-bats against him.