Oakland Athletics vs
Washington NationalsPredictions & Preview

Athletics Favored Over Nationals in Interleague Matchup with Strong Pitching Matchup, According to MLB Picks

On Wednesday, August 6, the 2025 MLB season continues with an interleague matchup between the Athletics and the Washington Nationals at Nationals Park in Washington, DC. The Athletics are favored to win with a -130 moneyline, and the total runs for the game is set at 9.0. This game is the second of a three-game series, with Tuesday's opener not factored into the prediction. For a detailed analysis and prediction of this matchup, continue reading our MLB picks for Wednesday's card. The first pitch is scheduled for 6:45 PM ET at Nationals Park.

Betting Odds

• Moneyline: Athletics -133 | Nationals +118
• Spread: Athletics -1.5 (+121) | Nationals +1.5 (-140)
• Total: Over/Under 8.5 (-110)
• Based on the moneyline, the implied probability that Oakland will win straight-up is 57%.

Oakland Athletics

The Oakland Athletics had a day off on Monday after going 3-3 in their last six games, winning two out of three against the Seattle Mariners and losing two out of three against the Arizona Diamondbacks. During this stretch, the team scored 23 runs with a .269/.329/.462 triple-slash. The bullpen has been strong, throwing 26.1 innings with a 2.73 ERA, 1.10 WHIP, and a .217 batting average against. Jeffrey Springs is set to start at Nationals Park on Wednesday, with a 10-7 record, 4.00 ERA, and 1.17 WHIP in 21 starts and two relief appearances. He has gone 4-1 in July and will look for his third consecutive win against the Nationals, having only allowed three earned runs in his last two starts spanning 12 innings.

Washington Nationals

The Washington Nationals are in the midst of a five-game losing streak and are looking to turn things around after a tough week where they went 1-5 in games against the Houston Astros and the Milwaukee Brewers. The team has struggled offensively, scoring only 21 runs in six games and has had difficulty in the bullpen, with a high ERA, WHIP, and batting average against. It is uncertain who will start for the Nationals on Wednesday, with the possibility of calling someone up from Triple-A Rochester or using a bullpen day. Cade Cavalli, the No. 6 prospect in the Nationals' rankings, is waiting for his chance after posting a 3-7 record with a 6.23 ERA in Triple-A.

A's Favored Over Nationals in Upcoming Game Due to Pitching Matchup

Recently, Jeffrey Springs has demonstrated strong performance on the mound, leading me to anticipate a continuation of his impressive form. Conversely, the Nationals have faced challenges hitting against left-handed pitchers in the past 10 days, resulting in a subpar .641 OPS and 82 wRC+ in 112 plate appearances. Given these factors, my prediction is in favor of the Athletics winning this upcoming game. The Nationals may choose to utilize a bullpen day, which has shown concerning results as of late. Even if Cade Cavalli is called up by the Nationals, my preference remains with the A's. In the same time frame, the A's have displayed a 109 wRC+ against right-handed pitchers and an impressive 120 wRC+ against left-handers.

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