Houston Astros vs
Miami MarlinsPredictions & Preview

Astros Favored in Interleague Matchup Against Marlins Despite Starting Pitching Concerns: MLB Prediction and Odds Update for Wednesday's Game

On Wednesday, August 6, 2025, the Houston Astros will face off against the Miami Marlins in an interleague matchup at loanDepot Park in Miami, Florida. The Astros are favored in this game with a total of 8.0 runs. The two teams are wrapping up their three-game series, with the Astros coming out on top 8-2 in the first game. Check out our Astros vs. Marlins prediction and the latest odds update for this exciting matchup. Stay tuned for more MLB picks for Wednesday's slate. The game is set to start at 4:40 PM ET.

Betting Odds

• Moneyline: Astros +103 | Marlins -114
• Spread: Astros +1.5 (-207) | Marlins -1.5 (+175)
• Total: Over/Under 8 (-110)
• Based on the moneyline, the implied probability that Miami will win straight-up is 53%.

Houston Astros

Last Monday, the Houston Astros, who were +110 underdogs, secured a victory over the Marlins thanks to Jason Alexander's strong pitching performance and Yainer Diaz's offensive contributions. The Astros went 6-for-12 with runners in scoring position, snapping a three-game losing streak. However, the team has been struggling overall, winning just three of their last 11 games. The offense has scored 37 runs with a .235/.295/.348 slash line, while the bullpen has a 4.03 ERA and 1.37 WHIP. Spencer Arrighetti will be activated from the 60-day IL to start Wednesday against the Marlins after recovering from a thumb injury. Arrighetti, with a 4.60 ERA and 1.38 WHIP in his career, has never faced the Marlins before.

Miami Marlins

The Miami Marlins had their five-game winning streak come to an end last Monday, as they were outhit by the Astros 11-7. Sandy Alcantara struggled, giving up six earned runs in seven innings. The Marlins managed to hit a couple of solo home runs, but their offense was lacking. Despite this loss, the Marlins have still won nine of their last 12 games. During this stretch, they have scored 53 runs with a .242/.318/.438 triple-slash. Their bullpen has a 4.66 ERA, 1.34 WHIP, and a .250 batting average against. Janson Junk is set to start on Wednesday, with a 5-2 record, 3.86 ERA, and 1.10 WHIP in 13 appearances this season. In his last three outings, he has struggled, allowing 15 runs on 20 hits. Junk has only faced the Astros once before in 2021, with five Houston players having experience against him, resulting in two singles in 12 at-bats.

Astros Favorable in Matchup Against Marlins Despite Starting Pitching Concerns

Spencer Arrighetti is set to return after a four-month absence, which raises concerns about his performance. However, considering the recent struggles of Janson Junk in his last three starts, I am inclined to favor the Astros in this upcoming game. Last week, Junk was ineffective, conceding six earned runs on six hits and a walk over five innings against the Yankees, resulting in a no-decision. Both teams have had subpar performances against right-handed pitchers in the last 10 days (Houston 91 wRC+, Miami 97 wRC+). The starting pitchers in this matchup are not particularly reliable. I anticipate that Arrighetti will have a limited pitch count, further emphasizing the importance of the Astros' bullpen.

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