Baltimore Orioles vs San Francisco Giants Betting Picks & Predictions
On Friday, August 29, 2025, the Baltimore Orioles will face off against the San Francisco Giants in an interleague showdown at Oracle Park in San Francisco, California. Last
Game outlook
On Friday, August 29, 2025, the Baltimore Orioles will face off against the San Francisco Giants in an interleague showdown at Oracle Park in San Francisco, California. Last year, the Giants won two out of three games against the Orioles in Baltimore, while two years ago, the Orioles won two out of three games at Oracle Park. For more information on this matchup and other MLB picks for Friday's games, read on. The game is set to start at 10:15 PM ET.
Betting Odds
Moneyline: Orioles +129 | Giants -142
Spread: Orioles +1.5 (-186) | Giants -1.5 (+158)
Total: Over/Under 7.5 (-110)
Based on the moneyline, the implied probability that San Francisco will win straight-up is 59%.
Baltimore Orioles
The Baltimore Orioles recently completed an eight-game homestand, only winning one game and losing seven. They struggled against the Houston Astros and were swept by the Boston Red Sox, scoring only seven runs while giving up 15 in return. The Orioles are currently last in the AL East and are trailing the bottom wild card team by 12 games. Dean Kremer is set to start on Friday night, with a 9-9 record, 4.19 ERA, and 1.23 WHIP in the 2025 season. Despite a rough outing last Saturday, Kremer has a 4.50 ERA in two career starts against the San Francisco Giants, with the current Giants lineup having success against him in the past.