Baltimore Orioles vs
San Francisco GiantsPredictions & Preview

Giants Favored in Interleague Showdown Against Orioles at Oracle Park

On Friday, August 29, 2025, the Baltimore Orioles will face off against the San Francisco Giants in an interleague showdown at Oracle Park in San Francisco, California. Last year, the Giants won two out of three games against the Orioles in Baltimore, while two years ago, the Orioles won two out of three games at Oracle Park. For more information on this matchup and other MLB picks for Friday's games, read on. The game is set to start at 10:15 PM ET.

Betting Odds

• Moneyline: Orioles +129 | Giants -142
• Spread: Orioles +1.5 (-186) | Giants -1.5 (+158)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that San Francisco will win straight-up is 59%.

Baltimore Orioles

The Baltimore Orioles recently completed an eight-game homestand, only winning one game and losing seven. They struggled against the Houston Astros and were swept by the Boston Red Sox, scoring only seven runs while giving up 15 in return. The Orioles are currently last in the AL East and are trailing the bottom wild card team by 12 games. Dean Kremer is set to start on Friday night, with a 9-9 record, 4.19 ERA, and 1.23 WHIP in the 2025 season. Despite a rough outing last Saturday, Kremer has a 4.50 ERA in two career starts against the San Francisco Giants, with the current Giants lineup having success against him in the past.

San Francisco Giants

Thursday's games have been excluded from the analysis. The 65-68 San Francisco Giants hosted the Chicago Cubs with the goal of sweeping a three-game series and extending their winning streak to five games. The Giants previously took two out of three games from the Brewers in Milwaukee. Despite their recent success, the Giants are currently third in the NL West and seven games behind the bottom wild card spot in the National League. It is unlikely that they will make the playoffs for the fourth straight year. The starting pitcher for the Giants in Friday night's game is still unknown, with the possibility of a bullpen day or calling up a player from the minors. Options include Kai-Wei Teng, who was recently sent down due to poor performance, and Blade Tidwell, a 24-year-old right-handed pitcher who has yet to make his debut for the Giants.

San Francisco Giants Favored Over Dean Kremer and the Orioles in upcoming matchup

The San Francisco Giants appear to be the favorable choice, even if they choose to utilize a bullpen day, due to concerns regarding Dean Kremer's reliability. While Kremer demonstrated strong performances in August with notable wins against the Astros and Mariners, his recent outings have been inconsistent, resulting in a less impressive ERA and FIP over his last six starts. In contrast, the Giants have shown proficiency against right-handed pitchers in recent games, supported by a solid OPS and wRC+. Additionally, the Giants' bullpen has demonstrated superior performance compared to the Orioles' bullpen, with lower ERA, WHIP, and batting average against. Therefore, based on recent trends and statistics, the Giants hold a competitive edge in this matchup.

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