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  1. Home
  2. MLB Picks
  3. San Diego Padres vs Minnesota Twins
Fri 8:10 PM ET
San Diego Padres logo
San Diego
Padres4
N. Cortes LHP
versus
Minnesota Twins logo
Minnesota
Twins7
Z. Matthews RHP
Final
Team123456789T
San Diego Padres0011002004
Minnesota Twins00142000

San Diego Padres vs Minnesota Twins Betting Picks & Predictions

Game time: August 29, 2025 at 8:10 PM ET

Venue: Target Field — Minneapolis, Minnesota

Article updated Aug 29, 11:46 PM EDT

Published by SportsJaw Editorial Team

In an upcoming interleague matchup, the San Diego Padres will face off against the Minnesota Twins at Target Field in Minneapolis, Minnesota on Friday night, with the game

Game outlook

In an upcoming interleague matchup, the San Diego Padres will face off against the Minnesota Twins at Target Field in Minneapolis, Minnesota on Friday night, with the game set to begin at 8:10 PM ET. Last year, the Padres won two out of three games against the Twins at Petco Park in San Diego. In this Padres vs. Twins prediction, the Padres are favored to win with a moneyline of -120 and a total of 8.5 runs. Stay tuned for more MLB picks for Friday's slate.

Betting Odds

Moneyline: Padres -121 | Twins +110

Spread: Padres -1.5 (+130) | Twins +1.5 (-150)

Total: Over/Under 9 (-110)

Based on the moneyline, the implied probability that San Diego will win straight-up is 55%.

San Diego Padres

The San Diego Padres have struggled in their recent games, dropping three out of their last four matchups. They suffered an 8-2 loss against the Los Angeles Dodgers and lost two out of three games against the Seattle Mariners. Despite this, the Padres remain two games behind the NL West-leading Dodgers and hold the second wild card spot in the National League. In their latest game against the Mariners, the Padres out hit their opponents but fell short, with Yu Darvish giving up four earned runs including a three-run homer. Nestor Cortes is set to pitch in the upcoming game against the Minnesota Twins, with a record of 2-2 and a 4.66 ERA this season. Cortes has performed well since joining the Padres at the trade deadline, with a 1-1 record and 3.00 ERA in four starts. He has had success against the Twins in the past, with a 2-2 record and a 4.13 ERA in five career starts and two relief appearances. Only four players on the current Twins team have faced Cortes before, with a combined total of one single, one double, and three home runs in 21 at-bats.

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MLB · San Diego Padres at Minnesota Twins

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Minnesota Twins

The Minnesota Twins have struggled in their recent games, winning only three out of their last 13 overall. They have lost four consecutive series and are currently 11.5 games behind the bottom wild card spot in the American League. In their most recent game, the Twins lost 9-8 to the Toronto Blue Jays, blowing an 8-5 lead. Pitcher Simeon Woods Richardson gave up five earned runs in 3.2 innings, with the bullpen adding four more runs. Zebby Matthews is set to pitch on Friday night, with a 3-4 record and 5.30 ERA in 2025. Matthews faced the Padres once in 2024, allowing five runs and has a 5-for-17 record against the current Padres lineup.

Nestor Cortes Shines as Twins Face Tough Matchup Against Padres' Strong Bullpen

Nestor Cortes delivered an impressive performance last Saturday by allowing only one hit in six scoreless innings during the Twins' 5-1 victory over the Dodgers. Despite the Twins' recent success against left-handed pitchers, I have confidence in Cortes' ability to perform well in this upcoming matchup. Additionally, the Padres have a strong bullpen that can be relied upon if Cortes encounters any challenges during the game. Over the past 10 days, the Padres' bullpen has exhibited impressive stats with a 3.57 ERA, 1.10 WHIP, and .192 batting average against, while the Twins' bullpen has posted a 4.14 ERA, 1.46 WHIP, and .255 batting average against. Considering the Padres' lineup has an impressive 116 wRC+ against right-handed pitchers during the same period, I am leaning towards the Padres as the more favorable choice over the Twins.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#SanDiegoPadres#MinnesotaTwins

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Padres vs Twins archived game preview contains historical odds and availability that may no longer be current. View history of past Padres vs Twins matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · San Diego Padres-125 → -124Moved
  • Moneyline · Minnesota Twins+108 → +109Moved
  • Spread · San Diego Padres-1.5 (+135) → -1.5 (+130)Moved
  • Spread · Minnesota Twins+1.5 (-158) → +1.5 (-150)Moved
  • Total · Over8.5 (-110) → 9 (-110)Moved
  • Total · Under8.5 (-110) → 9 (-110)Moved

ATS and O/U trends

San Diego Padres
91-71 matchup record · 7-3-0 ATS · 5-5-0 O/U
Last 10 completed games on file
Minnesota Twins
77-85 matchup record · 4-6-0 ATS · 7-2-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-30T03:46:35.342Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Minnesota Twins defeated San Diego Padres 7-4

Minnesota Twins defeated San Diego Padres 7-4 on August 29, 2025, a 3-run decision in the series. Minnesota Twins' strongest period was the 4th inning, when it outscored its opponent 4-1. Against SportsJaw's recorded San Diego Padres -1.5 (+130) spread, Minnesota Twins covered, while the 11 combined runs finished over the recorded total of 9.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.