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  1. Home
  2. MLB Picks
  3. Pittsburgh Pirates vs St. Louis Cardinals
Wed 7:45 PM ET
Pittsburgh Pirates logo
Pittsburgh
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C. Mlodzinski RHP
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St. Louis Cardinals logo
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S. Gray RHP
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Pittsburgh Pirates vs St. Louis Cardinals Betting Picks & Predictions

Game time: August 27, 2025 at 7:45 PM ET

Venue: Busch Stadium — St. Louis, Missouri

Article updated Aug 27, 2:14 PM EDT

Published by SportsJaw Editorial Team

The Pittsburgh Pirates (57-75) are facing the St Louis Cardinals (65-67) in the third game of a four-game series at Busch Stadium. Pittsburgh lost the opening game, ending a

Game outlook

The Pittsburgh Pirates (57-75) are facing the St Louis Cardinals (65-67) in the third game of a four-game series at Busch Stadium. Pittsburgh lost the opening game, ending a four-game winning streak. Both teams are far behind in the NL Central standings and wildcard race. Pittsburgh will be missing several players, including five pitchers and three position players, while St Louis will also be without some key players. Stay tuned for our detailed prediction on the outcome of this matchup.

Betting Odds

Moneyline: Pirates +149 | Cardinals -167

Spread: Pirates +1.5 (-142) | Cardinals -1.5 (+124)

Total: Over/Under 7.5 (-110)

Based on the moneyline, the implied probability that St. Louis will win straight-up is 63%.

Pittsburgh Pirates

The Pittsburgh Pirates currently rank 25th in both on-base percentage and batting average, and last in both runs scored and slugging percentage. Oneil Cruz leads the team in home runs with 18 and is second in RBI with 51, while Bryan Reynolds has 11 home runs and leads in RBI with 65. The Pirates have multiple players with 47 or more RBI, and have a total of 308 extra base hits in 132 games. On the pitching side, Pittsburgh ranks 5th in WHIP, 8th in batting average against, and 14th in both Quality Starts and ERA. Paul Skenes leads in wins, strikeouts, and ERA for starters. Braxton Ashcraft will pitch on Wednesday with a 4-2 record, 2.70 ERA, 1.18 WHIP, and 43 strikeouts this season.

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MLB · Pittsburgh Pirates at St. Louis Cardinals

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St. Louis Cardinals

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Pirates on a Winning Streak as Cardinals Struggle

The Pittsburgh Pirates have been on a successful streak, winning four of their last five games. In contrast, the St. Louis Cardinals have struggled recently, losing eight of their last 12 games and five of their last six home games. The Pirates have faced challenges offensively, ranking last in runs scored and slugging percentage. However, they have excelled on the pitching mound, boasting the fifth-best WHIP and 14th-best ERA in the league. On the other hand, the Cardinals rank 15th in runs scored and 24th in slugging percentage, with a 21st ranking in both ERA and WHIP. Pittsburgh's starter, Braxton Ashcraft, has delivered strong performances in his last four outings, allowing only four runs in 15.2 innings. In contrast, St. Louis's starter, Sonny Gray, has struggled in his past two games, giving up 15 hits and nine runs in 10.0 innings. Additionally, St. Louis is currently missing key players like Nolan Arenado and Brendan Donovan.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#PittsburghPirates#StLouisCardinals

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Pirates vs Cardinals archived game preview contains historical odds and availability that may no longer be current. View history of past Pirates vs Cardinals matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Pittsburgh Pirates+158 → +148Moved
  • Moneyline · St. Louis Cardinals-190 → -174Moved
  • Spread · Pittsburgh Pirates+1.5 (-137) → +1.5 (-145)Moved
  • Spread · St. Louis Cardinals-1.5 (+115) → -1.5 (+124)Moved
  • Total · Over7.5 (-110) → 7.5 (-110)Unchanged
  • Total · Under7.5 (-110) → 7.5 (-110)Unchanged

ATS and O/U trends

Pittsburgh Pirates
82-80 matchup record · 8-2-0 ATS · 4-4-2 O/U
Last 10 completed games on file
St. Louis Cardinals
77-85 matchup record · 3-7-0 ATS · 8-1-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-27T18:14:43.759Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2025-08-26Pittsburgh Pirates 8 · St. Louis Cardinals 3
  • 2025-08-25Pittsburgh Pirates 6 · St. Louis Cardinals 7
Final result

Matchup pick recap

Pittsburgh Pirates defeated St. Louis Cardinals 2-1

Pittsburgh Pirates defeated St. Louis Cardinals 2-1 on August 27, 2025, a 1-run decision in the series. Pittsburgh Pirates' strongest period was the 6th inning, when it outscored its opponent 2-0. Against SportsJaw's recorded Pittsburgh Pirates +1.5 (-145) spread, Pittsburgh Pirates covered, while the 3 combined runs finished under the recorded total of 7.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.