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  1. Home
  2. MLB Picks
  3. Chicago Cubs vs San Francisco Giants
Wed 9:45 PM ET
Chicago Cubs logo
Chicago
Cubs3
C. REA RHP
versus
San Francisco Giants logo
San Francisco
Giants12
C. Whisenhunt LHP
Final
Team123456789T
Chicago Cubs0300000003
San Francisco Giants10303311

Chicago Cubs vs San Francisco Giants Betting Picks & Predictions

Game time: August 27, 2025 at 9:45 PM ET

Venue: Oracle Park — San Francisco, California

Article updated Aug 27, 11:48 PM EDT

Published by SportsJaw Editorial Team

In Wednesday night's matchup at Oracle Park, the Giants and Cubs will face off for the second game of their three-game series. The Giants secured a 5-2 victory in the opener,

Game outlook

In Wednesday night's matchup at Oracle Park, the Giants and Cubs will face off for the second game of their three-game series. The Giants secured a 5-2 victory in the opener, with Justin Verlander earning his first home win with San Francisco. Despite the loss, the Cubs have shown strength on the road this season, boasting a 35-31 record away from Wrigley Field. Stay tuned for our Giants vs Cubs prediction for tonight's game.

Betting Odds

Moneyline: Cubs -127 | Giants +115

Spread: Cubs -1.5 (+130) | Giants +1.5 (-150)

Total: Over/Under 8.5 (-110)

Based on the moneyline, the implied probability that Chicago will win straight-up is 56%.

Chicago Cubs

The Chicago Cubs enter Wednesday's game with a 89-73 record, with 35 wins on the road. The team has been successful due to strong defense and starting pitching, although scoring runs has been a challenge recently. Right-hander Colin Rea will start the game with a 4.34 ERA, 93 strikeouts, and 38 walks. Rea has been effective in keeping the team competitive by limiting big innings. The Cubs will face a left-handed pitcher in Whisenhunt after struggling against Verlander on Tuesday. Key contributors to Chicago's offense include Pete Crow-Armstrong with 28 home runs and 82 RBI, and Seiya Suzuki with 27 home runs and 87 RBI.

San Francisco Giants

The San Francisco Giants have a record of 65-97, with a 31-33 record at Oracle Park. In a recent game, home runs from Wilmer Flores and Matt Chapman, along with a key RBI from Rafael Devers, powered the offense. This glimpse of timely hitting is what the team has been looking for. Left-hander Carson Whisenhunt will start the next game with a 5.00 ERA in just over 18 innings as a big leaguer. Although he has shown potential with 13 strikeouts, his command has been inconsistent, leading to pressure on the bullpen. Offensively, Willy Adames leads the team with 22 home runs and 65 RBI, while Heliot Ramos and Wilmer Flores are also having impressive seasons with 15 and 14 home runs respectively.

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12
MLB · Chicago Cubs at San Francisco Giants

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21+. Gambling problem? Call 1-800-GAMBLER. Picks are opinions, not guarantees. Past results do not predict future outcomes.

Cubs' Experience and Resilience Give Them Advantage over Giants in Pitching Matchup

The Cubs hold a significant advantage in experience with Rea pitching, compared to the inexperienced Whisenhunt. Chicago has exhibited strong performance on the road throughout the season and has shown resilience after losses. The Giants' lineup has shown improvement recently, but Whisenhunt's lack of experience against a disciplined and contact-heavy Cubs offense may present challenges. It is recommended to support Chicago to take an early lead and rely on their veteran players. The Cubs are considered the favored team for valid reasons.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#ChicagoCubs#SanFranciscoGiants

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Cubs vs Giants archived game preview contains historical odds and availability that may no longer be current. View history of past Cubs vs Giants matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Chicago Cubs-125 → -127Moved
  • Moneyline · San Francisco Giants+107 → +114Moved
  • Spread · Chicago Cubs-1.5 (+135) → -1.5 (+130)Moved
  • Spread · San Francisco Giants+1.5 (-155) → +1.5 (-150)Moved
  • Total · Over8.5 (-110) → 8.5 (-110)Unchanged
  • Total · Under8.5 (-110) → 8.5 (-110)Unchanged

ATS and O/U trends

Chicago Cubs
89-73 matchup record · 4-6-0 ATS · 3-7-0 O/U
Last 10 completed games on file
San Francisco Giants
65-97 matchup record · 6-3-1 ATS · 4-5-1 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-28T03:48:07.367Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

  • 2025-08-26Chicago Cubs 2 · San Francisco Giants 5
Final result

Matchup pick recap

San Francisco Giants defeated Chicago Cubs 12-3

San Francisco Giants defeated Chicago Cubs 12-3 on August 27, 2025, a 9-run decision in the series. San Francisco Giants' strongest period was the 3rd inning, when it outscored its opponent 3-0. Against SportsJaw's recorded Chicago Cubs -1.5 (+130) spread, San Francisco Giants covered, while the 15 combined runs finished over the recorded total of 8.5.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.