San Diego Padres vs
Seattle MarinersPredictions & Preview

San Diego Padres Look to Get Revenge Against Seattle Mariners in Interleague Rematch at T-Mobile Park

The San Diego Padres are set to take on the Seattle Mariners in an interleague matchup at T-Mobile Park on Tuesday, August 26. The Mariners have a slight advantage as -112 favorites, with a total of 7.5 runs expected for the game. The teams have already met earlier in the season, with the Mariners sweeping the Padres in a three-game series in May. This preview provides insight into the upcoming matchup and offers a prediction for the game. The first pitch is scheduled for 9:40 PM ET.

Betting Odds

• Moneyline: Padres +100 | Mariners -115
• Spread: Padres +1.5 (-200) | Mariners -1.5 (+170)
• Total: Over/Under 7.5 (-110)
• Based on the moneyline, the implied probability that Seattle will win straight-up is 53%.

San Diego Padres

The San Diego Padres recently won their last two series against the San Francisco Giants and Los Angeles Dodgers, taking three out of four from the Giants and two out of three from the Dodgers. As of Monday morning, the 74-57 Padres were tied with the Dodgers in the NL West. Despite a loss to the Dodgers last Sunday, ending a five-game winning streak, the Padres have been performing well offensively, scoring 30 runs over their last six games. The bullpen has also been strong, with a 3.32 ERA and a .179 batting average against. Dylan Cease is set to pitch against the Mariners on Tuesday night, with a 6-11 record, 4.71 ERA, and 1.32 WHIP in 2025. Cease has recorded 178 strikeouts this season but has struggled with run prevention. In his only previous meeting with the Mariners in 2019, they have had success against him, going 19-for-71 with four doubles, four home runs, and 15 RBI.

Seattle Mariners

The Seattle Mariners have been facing difficulties recently, losing three of their last four series and posting a 3-8 record in their last 11 games. Despite this, they remain in contention for a wild card spot in the American League, sitting two games behind the AL West-leading Houston Astros. Over the weekend, the Mariners were able to take two out of three games from the Athletics. However, they have struggled to score runs and their bullpen has struggled with a high ERA and WHIP in recent games. Luis Castillo is set to start for the Mariners and has a solid record this season, but will be facing a tough challenge against the Padres, who have had success against him in the past.

Dylan Cease vs Luis Castillo: Anticipated Pitching Duel in Middle Game of Series

Anticipated is a closely contested match in the forthcoming middle game of this series. Dylan Cease's performance throughout the season has been erratic, contrasting with Luis Castillo's recent struggles. Cease holds a record of 3-1, accompanied by a 4.19 ERA and 3.58 FIP in August across four starts totaling 19.1 innings pitched. In comparison, Castillo has endured a winless streak this month, accumulating a 6.05 ERA and 6.94 FIP over four starts totaling 19.1 innings pitched. Consequently, my preference leans towards the Padres, considering both lineups' commendable performances against right-handed pitchers in the past 10 days (San Diego 112 wRC+, Seattle 108 wRC+). Furthermore, the Padres' strong bullpen could potentially be the deciding factor as the game progresses.

Sources: [ 2 ] [ 3 ]