Chicago Cubs vs Los Angeles Angels Betting Picks & Predictions
The Chicago Cubs will face off against the Los Angeles Angels in an interleague battle at Angel Stadium in Anaheim, CA on Friday, August 22, 2025. Last year, the Cubs won two
Game outlook
The Chicago Cubs will face off against the Los Angeles Angels in an interleague battle at Angel Stadium in Anaheim, CA on Friday, August 22, 2025. Last year, the Cubs won two out of three games against the Angels in Chicago, with all three games going under the total. Our prediction for this game and other MLB picks for Friday's card can be found here. The first pitch at Angel Stadium is set for 9:38 PM ET.
Betting Odds
Moneyline: Cubs -125 | Angels +113
Spread: Cubs -1.5 (+122) | Angels +1.5 (-142)
Total: Over/Under 9.5 (-110)
Based on the moneyline, the implied probability that Chicago will win straight-up is 56%.
Chicago Cubs
The Chicago Cubs hosted the Milwaukee Brewers for the final game of their five-game series, with the Cubs winning the last three games after an initial loss. Chicago is currently six games behind the NL Central-leading Brewers and holds the top wild card in the National League. Despite struggling offensively in their last 10 games, the Cubs' bullpen has performed well, with a 2.78 ERA. The starting pitcher for the Cubs on Friday night was still to be determined at the time of writing, with Javier Assad a potential candidate after pitching effectively in his last outing.
Los Angeles Angels
The Los Angeles Angels recently secured a 2-1 victory over the Cincinnati Reds, avoiding a sweep in a three-game series. Despite this win, they have lost consecutive series against the Athletics and the Reds, and currently stand 6.5 games behind the bottom wild card in the American League. Over their previous 10 games, the Angels have scored 48 runs and maintained a .234/.332/.404 slash line. However, their bullpen has struggled, with a 4.61 ERA, 1.41 WHIP, and .243 batting average against in 41 innings pitched during this stretch. Tyler Anderson is set to start on Friday, with a 2-8 record, 4.77 ERA, and 1.42 WHIP in 24 starts this season. In August, he has gone 0-2 with a 7.71 ERA. Although Anderson has a 3.69 ERA in 11 career starts against the Cubs, they have had success against him in the past, with a 45-for-127 record including 10 doubles, three triples, and seven home runs.