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  1. Home
  2. MLB Picks
  3. Cincinnati Reds vs Arizona Diamondbacks
Fri 9:40 PM ET
Cincinnati Reds logo
Cincinnati
Reds5
Z. Littell RHP
versus
Arizona Diamondbacks logo
Arizona
Diamondbacks6
R. Nelson RHP
Final/11
Team1234567891011T
Cincinnati Reds020001010105
Arizona Diamondbacks10

Cincinnati Reds vs Arizona Diamondbacks Betting Picks & Predictions

Game time: August 22, 2025 at 9:40 PM ET

Venue: Chase Field — Phoenix, Arizona

Article updated Aug 22, 11:46 PM EDT

Published by SportsJaw Editorial Team

The Cincinnati Reds are facing the Arizona Diamondbacks in an important National League weekend matchup starting on Friday, Aug. 22. The Reds, with a 75-87 record, are just

Game outlook

The Cincinnati Reds are facing the Arizona Diamondbacks in an important National League weekend matchup starting on Friday, Aug. 22. The Reds, with a 75-87 record, are just one game back of a wild card spot as the season nears its end. The Diamondbacks, on the other hand, are 62-66 and falling out of playoff contention. Zack Littell is set to start for the Reds, while Ryne Nelson will take the mound for the Diamondbacks. The game is scheduled to begin at 9:40 P.M. EST.

Betting Odds

Moneyline: Reds +116 | Diamondbacks -130

Spread: Reds +1.5 (-175) | Diamondbacks -1.5 (+155)

Total: Over/Under 9 (-110)

Based on the moneyline, the implied probability that Arizona will win straight-up is 57%.

Cincinnati Reds

Cincinnati Reds currently have a 67-61 overall record, placing them in third in the National League Central division and 13 games behind the Brewers for first place. They are also one game back of the Mets for the final wild card spot in the National League. The team has a 31-32 record when playing on the road and has won seven of their last 11 games. Despite losing their last game to the Angels, the Reds did take the series. Zack Littell will be starting for the Reds against the Diamondbacks with a 9-8 record and a 3.52 ERA in 25 starts. He has a 3.06 ERA in three starts with the Reds and a 3.76 ERA when throwing on the road. The Reds have a .248 batting average this season, ranking 16th in the league, scoring the 12th most runs and ranking 16th in hits. They have hit the ninth fewest home runs and struck out the eighth fewest times. Against Arizona this year, they have a .265 batting average, and against NL West clubs, they have a .260 batting average.

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MLB · Cincinnati Reds at Arizona Diamondbacks

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Arizona Diamondbacks

The Arizona Diamondbacks currently have a record of 62-66 this season and are in third place in the National League West division. They are 11 games behind the Dodgers for first place and 5.5 games back of the Mets for the final wild card spot. The team has a 32-31 record when playing at home. After losing four straight games, they have won their last two games against the Guardians, including a 3-2 win in 10 innings on Wednesday. Ryne Nelson will be starting for the Diamondbacks against the Reds on Friday. Despite a 6-3 record with a 3.58 ERA, the team has lost the past four straight games that Nelson has started. The Diamondbacks have a .251 team batting average this season, ranking 11th in the league, and have hit the fifth most home runs. They have a .264 average in August and a .248 average against NL Central clubs.

Reds Favored Over Diamondbacks in Weekend Showdown as Playoff Race Heats Up

This upcoming weekend presents a significant opportunity for the Reds and Diamondbacks. Cincinnati has the chance to strengthen its position in the race for a wild-card spot, while Arizona is aiming to remain competitive. The Reds appear poised to secure a victory in this game and throughout the weekend, particularly with Zack Littell on the mound. Littell has demonstrated strong performance with a 3.76 ERA on the road and a 2-1 record since joining the team. On the other hand, the Diamondbacks will start Ryne Nelson, who has a 3.38 ERA post-All-Star break. However, Arizona's recent offensive struggles have resulted in four consecutive losses in games started by Nelson. Considering these factors, it is advisable to favor the Reds in this matchup.

SportsJawGame Predictions
Predicted score

Unavailable for this preview

Projected winnerUnavailableConfidencelow
Pick on the Spread

Published pick: Unavailable

Pick on the Total

Published pick: Unavailable

#CincinnatiReds#ArizonaDiamondbacks

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Written by

SportsJaw Editorial Team

SportsJaw published this archived preview from its original game-day article. Its prediction and quoted lines are preserved as written.

About our editorial process

SportsJaw Reds vs Diamondbacks archived game preview contains historical odds and availability that may no longer be current. View history of past Reds vs Diamondbacks matchups or learn how our predictions work.

Current matchup data

Lines, trends and availability

Line movement since open

  • Moneyline · Cincinnati Reds+117 → +115Moved
  • Moneyline · Arizona Diamondbacks-130 → -130Unchanged
  • Spread · Cincinnati Reds+1.5 (-175) → +1.5 (-175)Unchanged
  • Spread · Arizona Diamondbacks-1.5 (+153) → -1.5 (+155)Moved
  • Total · Over9 (-110) → 9 (-110)Unchanged
  • Total · Under9 (-110) → 9 (-110)Unchanged

ATS and O/U trends

Cincinnati Reds
75-87 matchup record · 7-3-0 ATS · 4-5-1 O/U
Last 10 completed games on file
Arizona Diamondbacks
86-76 matchup record · 4-6-0 ATS · 4-6-0 O/U
Last 10 completed games on file

Injuries and availability

From the published research (2025-08-23T03:46:06.591Z). Availability may have changed; review the cited sources.

No verified injury or availability note was included in the published matchup research.

Recent head-to-head

No completed head-to-head result is available in the current history window.

Final result

Matchup pick recap

Arizona Diamondbacks defeated Cincinnati Reds 6-5

Arizona Diamondbacks defeated Cincinnati Reds 6-5 on August 22, 2025, a 1-run decision in the series. Arizona Diamondbacks' strongest period was the 3rd inning, when it outscored its opponent 3-0. Against SportsJaw's recorded Cincinnati Reds +1.5 (-175) spread, Cincinnati Reds covered, while the 11 combined runs finished over the recorded total of 9.

SportsJaw editorial picks

  • Projected winnerNo published selectionUnavailable

Tipster picks

No graded public tipster picks were recorded for this matchup.